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Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C
BACKGROUND/AIMS: Sustained virologic response (SVR) for the treatment of chronic hepatitis C (CHC) may differ with ethnicity due to differences in genetic traits. This study evaluated the efficacy of peginterferon and ribavirin, and the association between IL28B genotypes and the treatment efficacy...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Association for the Study of the Liver
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540372/ https://www.ncbi.nlm.nih.gov/pubmed/23323251 http://dx.doi.org/10.3350/cmh.2012.18.4.360 |
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author | Jeong, Seok Hoo Jung, Young Kul Yang, Jae Won Park, Sang Jin Kim, Jong Woo Kwon, Oh Sang Kim, Yun Soo Choi, Duck Joo Kim, Ju Hyun |
author_facet | Jeong, Seok Hoo Jung, Young Kul Yang, Jae Won Park, Sang Jin Kim, Jong Woo Kwon, Oh Sang Kim, Yun Soo Choi, Duck Joo Kim, Ju Hyun |
author_sort | Jeong, Seok Hoo |
collection | PubMed |
description | BACKGROUND/AIMS: Sustained virologic response (SVR) for the treatment of chronic hepatitis C (CHC) may differ with ethnicity due to differences in genetic traits. This study evaluated the efficacy of peginterferon and ribavirin, and the association between IL28B genotypes and the treatment efficacy in Korean CHC patients. METHODS: This was a retrospective cohort study using data from medical records. Eighty-five CHC patients were eligible for assessment of the efficacy of antiviral therapy, and 47 patients were available for an IL28B genetic study, which was performed using the Multiplex tetra-primer PCR method for rs12979860. RESULTS: Overall, the early virologic response rate was 87.1%: 84.9% in HCV genotype 1 and 90.6% in genotype 2. The overall end-of-treatment virologic response rate was 81.2%: 75.5% in genotype 1 and 90.6% in genotype 2. The overall SVR rate was 81.2%: 75.5% in genotype 1 and 90.6% in genotype 2. For rs12979860, the frequencies of polymorphisms were 89% for the CC type, 11% for the CT type, and 0% for the TT type. Their overall SVR rate was 87% (39/47): 90.5% (38/42) for the CC type and 20% (1/5) for the CT type. For genotype 1, SVR rates were 88% (21/24) for the CC type and 0% (0/4) for the CT type. Multivariate analysis revealed that the IL28B-CC type was a good predictor for SVR. CONCLUSIONS: The SVR of the combination therapy in Koreans was higher than that observed in Western countries. This finding might be attributable to the high prevalence of IL28B-CC type among Koreans, which may be a good predictor of SVR. |
format | Online Article Text |
id | pubmed-3540372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Association for the Study of the Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-35403722013-01-15 Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C Jeong, Seok Hoo Jung, Young Kul Yang, Jae Won Park, Sang Jin Kim, Jong Woo Kwon, Oh Sang Kim, Yun Soo Choi, Duck Joo Kim, Ju Hyun Clin Mol Hepatol Original Article BACKGROUND/AIMS: Sustained virologic response (SVR) for the treatment of chronic hepatitis C (CHC) may differ with ethnicity due to differences in genetic traits. This study evaluated the efficacy of peginterferon and ribavirin, and the association between IL28B genotypes and the treatment efficacy in Korean CHC patients. METHODS: This was a retrospective cohort study using data from medical records. Eighty-five CHC patients were eligible for assessment of the efficacy of antiviral therapy, and 47 patients were available for an IL28B genetic study, which was performed using the Multiplex tetra-primer PCR method for rs12979860. RESULTS: Overall, the early virologic response rate was 87.1%: 84.9% in HCV genotype 1 and 90.6% in genotype 2. The overall end-of-treatment virologic response rate was 81.2%: 75.5% in genotype 1 and 90.6% in genotype 2. The overall SVR rate was 81.2%: 75.5% in genotype 1 and 90.6% in genotype 2. For rs12979860, the frequencies of polymorphisms were 89% for the CC type, 11% for the CT type, and 0% for the TT type. Their overall SVR rate was 87% (39/47): 90.5% (38/42) for the CC type and 20% (1/5) for the CT type. For genotype 1, SVR rates were 88% (21/24) for the CC type and 0% (0/4) for the CT type. Multivariate analysis revealed that the IL28B-CC type was a good predictor for SVR. CONCLUSIONS: The SVR of the combination therapy in Koreans was higher than that observed in Western countries. This finding might be attributable to the high prevalence of IL28B-CC type among Koreans, which may be a good predictor of SVR. The Korean Association for the Study of the Liver 2012-12 2012-12-21 /pmc/articles/PMC3540372/ /pubmed/23323251 http://dx.doi.org/10.3350/cmh.2012.18.4.360 Text en Copyright © 2012 by The Korean Association for the Study of the Liver http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jeong, Seok Hoo Jung, Young Kul Yang, Jae Won Park, Sang Jin Kim, Jong Woo Kwon, Oh Sang Kim, Yun Soo Choi, Duck Joo Kim, Ju Hyun Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C |
title | Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C |
title_full | Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C |
title_fullStr | Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C |
title_full_unstemmed | Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C |
title_short | Efficacy of peginterferon and ribavirin is associated with the IL28B gene in Korean patients with chronic hepatitis C |
title_sort | efficacy of peginterferon and ribavirin is associated with the il28b gene in korean patients with chronic hepatitis c |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540372/ https://www.ncbi.nlm.nih.gov/pubmed/23323251 http://dx.doi.org/10.3350/cmh.2012.18.4.360 |
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