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Long Non-Coding RNAs in Infection Biology
Long non-coding RNA have emerged as an increasingly well studied subset of non-coding RNAs (ncRNAs) following their recent discovery in a number of organisms including humans and characterization of their functional and regulatory roles in variety of distinct cellular mechanisms. The recent annotati...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540418/ https://www.ncbi.nlm.nih.gov/pubmed/23316211 http://dx.doi.org/10.3389/fgene.2012.00308 |
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author | Scaria, Vinod Pasha, Ayesha |
author_facet | Scaria, Vinod Pasha, Ayesha |
author_sort | Scaria, Vinod |
collection | PubMed |
description | Long non-coding RNA have emerged as an increasingly well studied subset of non-coding RNAs (ncRNAs) following their recent discovery in a number of organisms including humans and characterization of their functional and regulatory roles in variety of distinct cellular mechanisms. The recent annotations of long ncRNAs in humans peg their numbers as similar to protein-coding genes. However, despite the rapid advancements in the field the functional characterization and biological roles of most of the long ncRNAs still remain unidentified, although some candidate long ncRNAs have been extensively studied for their roles in cancers and biological phenomena such as X-inactivation and epigenetic regulation of genes. A number of recent reports suggest an exciting possibility of long ncRNAs mediating host response and immune function, suggesting an elaborate network of regulatory interactions mediated through ncRNAs in infection. The present role of long ncRNAs in host-pathogen cross talk is limited to a handful of mechanistically distinct examples. The current commentary chronicles the findings of these reports on the role of long ncRNAs in infection biology and further highlights the bottlenecks and future directions toward understanding the biological significance of the role of long ncRNAs in infection biology. |
format | Online Article Text |
id | pubmed-3540418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35404182013-01-11 Long Non-Coding RNAs in Infection Biology Scaria, Vinod Pasha, Ayesha Front Genet Genetics Long non-coding RNA have emerged as an increasingly well studied subset of non-coding RNAs (ncRNAs) following their recent discovery in a number of organisms including humans and characterization of their functional and regulatory roles in variety of distinct cellular mechanisms. The recent annotations of long ncRNAs in humans peg their numbers as similar to protein-coding genes. However, despite the rapid advancements in the field the functional characterization and biological roles of most of the long ncRNAs still remain unidentified, although some candidate long ncRNAs have been extensively studied for their roles in cancers and biological phenomena such as X-inactivation and epigenetic regulation of genes. A number of recent reports suggest an exciting possibility of long ncRNAs mediating host response and immune function, suggesting an elaborate network of regulatory interactions mediated through ncRNAs in infection. The present role of long ncRNAs in host-pathogen cross talk is limited to a handful of mechanistically distinct examples. The current commentary chronicles the findings of these reports on the role of long ncRNAs in infection biology and further highlights the bottlenecks and future directions toward understanding the biological significance of the role of long ncRNAs in infection biology. Frontiers Media S.A. 2013-01-09 /pmc/articles/PMC3540418/ /pubmed/23316211 http://dx.doi.org/10.3389/fgene.2012.00308 Text en Copyright © 2013 Scaria and Pasha. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Genetics Scaria, Vinod Pasha, Ayesha Long Non-Coding RNAs in Infection Biology |
title | Long Non-Coding RNAs in Infection Biology |
title_full | Long Non-Coding RNAs in Infection Biology |
title_fullStr | Long Non-Coding RNAs in Infection Biology |
title_full_unstemmed | Long Non-Coding RNAs in Infection Biology |
title_short | Long Non-Coding RNAs in Infection Biology |
title_sort | long non-coding rnas in infection biology |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540418/ https://www.ncbi.nlm.nih.gov/pubmed/23316211 http://dx.doi.org/10.3389/fgene.2012.00308 |
work_keys_str_mv | AT scariavinod longnoncodingrnasininfectionbiology AT pashaayesha longnoncodingrnasininfectionbiology |