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Defects of mtDNA Replication Impaired Mitochondrial Biogenesis During Trypanosoma cruzi Infection in Human Cardiomyocytes and Chagasic Patients: The Role of Nrf1/2 and Antioxidant Response

BACKGROUND: Mitochondrial dysfunction is a key determinant in chagasic cardiomyopathy development in mice; however, its relevance in human Chagas disease is not known. We determined if defects in mitochondrial biogenesis and dysregulation of peroxisome proliferator-activated receptor gamma (PPARγ) c...

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Detalles Bibliográficos
Autores principales:	Wan, Xianxiu, Gupta, Shivali, Zago, Maria P., Davidson, Mercy M., Dousset, Pierre, Amoroso, Alejandro, Garg, Nisha Jain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540675/ https://www.ncbi.nlm.nih.gov/pubmed/23316324 http://dx.doi.org/10.1161/JAHA.112.003855

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