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Molecular Mechanisms and Function Prediction of Long Noncoding RNA

The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large...

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Detalles Bibliográficos
Autores principales: Ma, Handong, Hao, Yun, Dong, Xinran, Gong, Qingtian, Chen, Jingqi, Zhang, Jifeng, Tian, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540756/
https://www.ncbi.nlm.nih.gov/pubmed/23319885
http://dx.doi.org/10.1100/2012/541786
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author Ma, Handong
Hao, Yun
Dong, Xinran
Gong, Qingtian
Chen, Jingqi
Zhang, Jifeng
Tian, Weidong
author_facet Ma, Handong
Hao, Yun
Dong, Xinran
Gong, Qingtian
Chen, Jingqi
Zhang, Jifeng
Tian, Weidong
author_sort Ma, Handong
collection PubMed
description The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs.
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spelling pubmed-35407562013-01-14 Molecular Mechanisms and Function Prediction of Long Noncoding RNA Ma, Handong Hao, Yun Dong, Xinran Gong, Qingtian Chen, Jingqi Zhang, Jifeng Tian, Weidong ScientificWorldJournal Review Article The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs. The Scientific World Journal 2012-12-23 /pmc/articles/PMC3540756/ /pubmed/23319885 http://dx.doi.org/10.1100/2012/541786 Text en Copyright © 2012 Handong Ma et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ma, Handong
Hao, Yun
Dong, Xinran
Gong, Qingtian
Chen, Jingqi
Zhang, Jifeng
Tian, Weidong
Molecular Mechanisms and Function Prediction of Long Noncoding RNA
title Molecular Mechanisms and Function Prediction of Long Noncoding RNA
title_full Molecular Mechanisms and Function Prediction of Long Noncoding RNA
title_fullStr Molecular Mechanisms and Function Prediction of Long Noncoding RNA
title_full_unstemmed Molecular Mechanisms and Function Prediction of Long Noncoding RNA
title_short Molecular Mechanisms and Function Prediction of Long Noncoding RNA
title_sort molecular mechanisms and function prediction of long noncoding rna
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540756/
https://www.ncbi.nlm.nih.gov/pubmed/23319885
http://dx.doi.org/10.1100/2012/541786
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