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Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)

The apical Na(+)-dependent bile salt transporter (ASBT/SLC10A2) is essential for maintaining the enterohepatic circulation of bile salts. It is not known when Slc10a2 evolved as a bile salt transporter or how it adapted to substantial changes in bile salt structure during evolution. We characterized...

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Detalles Bibliográficos
Autores principales:	Lionarons, Daniël A., Boyer, James L., Cai, Shi-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540847/ https://www.ncbi.nlm.nih.gov/pubmed/22669917 http://dx.doi.org/10.1194/jlr.M025726

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