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A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion

Alzheimer’s disease is one of the most prevalent neurodegenerative disorders. However, there is no current treatment, which definitively influences disease progression over a sustained period. Numerous studies linking an increase in serum cholesterol, mainly during midlife, with the pathogenic proce...

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Detalles Bibliográficos
Autores principales: Sánchez-Ferro, Álvaro, Benito-León, Julián, Mitchell, Alex J, Bermejo-Pareja, Félix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540910/
https://www.ncbi.nlm.nih.gov/pubmed/23319866
http://dx.doi.org/10.2147/NDT.S29105
Descripción
Sumario:Alzheimer’s disease is one of the most prevalent neurodegenerative disorders. However, there is no current treatment, which definitively influences disease progression over a sustained period. Numerous studies linking an increase in serum cholesterol, mainly during midlife, with the pathogenic process of Alzheimer’s disease have been published. Therefore, the role of statins as a therapy in this disorder may be of great interest. The aim of the present review is to summarize of the role of statins in the treatment of Alzheimer’s disease.