Combination of a Proteomics Approach and Reengineering of Meso Scale Network Models for Prediction of Mode-of-Action for Tyrosine Kinase Inhibitors

In drug discovery, the characterisation of the precise modes of action (MoA) and of unwanted off-target effects of novel molecularly targeted compounds is of highest relevance. Recent approaches for identification of MoA have employed various techniques for modeling of well defined signaling pathway...

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Detalles Bibliográficos
Autores principales: Balabanov, Stefan, Wilhelm, Thomas, Venz, Simone, Keller, Gunhild, Scharf, Christian, Pospisil, Heike, Braig, Melanie, Barett, Christine, Bokemeyer, Carsten, Walther, Reinhard, Brümmendorf, Tim H., Schuppert, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541187/
https://www.ncbi.nlm.nih.gov/pubmed/23326482
http://dx.doi.org/10.1371/journal.pone.0053668

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