Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells

BACKGROUND: The primary, stable metabolite of nicotine [(S)-3-(1-methyl-2-pyrrolidinyl) pyridine] in humans is cotinine [(S)-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone]. We have previously shown that cotinine exposure induces convergence and amplification of the GSK3β-dependent PI3 kinase and choliner...

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Detalles Bibliográficos
Autores principales: Bagaitkar, Juhi, Zeller, Iris, Renaud, Diane E, Scott, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541225/
https://www.ncbi.nlm.nih.gov/pubmed/23176969
http://dx.doi.org/10.1186/1617-9625-10-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541225/
https://www.ncbi.nlm.nih.gov/pubmed/23176969
http://dx.doi.org/10.1186/1617-9625-10-18

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