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Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors

Deregulated apoptosis is a hallmark of cancer, and the B-cell lymphoma-2 (Bcl-2) family of proteins is pivotal to mediating the intrinsic pathway of this process. Recent advances have yielded both pan-Bcl-2 small molecule inhibitors (SMIs) that inhibit both the Bcl-2 and the Mcl-1 arm of the Bcl-2 f...

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Detalles Bibliográficos
Autores principales:	Liu, Qiang, Wang, Hong-Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2012
Materias:	Mini Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541322/ https://www.ncbi.nlm.nih.gov/pubmed/23336025 http://dx.doi.org/10.4161/cib.21554

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