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Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors
Neurons have unique challenges relative to other cell types. Unlike most other cells, neurons must remain healthy and functional throughout the lifespan of an animal. Premature neuronal loss underlies many age-related neurodegenerative diseases, including Alzheimer and Parkinson Diseases. Despite pr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541331/ https://www.ncbi.nlm.nih.gov/pubmed/23740166 http://dx.doi.org/10.4161/cib.21434 |
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author | Mejia, Jonathan Haberman, Adam |
author_facet | Mejia, Jonathan Haberman, Adam |
author_sort | Mejia, Jonathan |
collection | PubMed |
description | Neurons have unique challenges relative to other cell types. Unlike most other cells, neurons must remain healthy and functional throughout the lifespan of an animal. Premature neuronal loss underlies many age-related neurodegenerative diseases, including Alzheimer and Parkinson Diseases. Despite previous research aimed at understanding the mechanisms of age-related neurodegenerative diseases, little is known about the mechanisms that allow neurons to remain functional for the lifetime of a healthy animal. Understanding these cellular and biochemical processes is essential to promote healthful aging and reduce the severity of neurodegenerative disease. Here we discuss our recent identification of neuron-specific proteins that regulate endosome fusion events and the role of endosomes in maintaining healthy neurons. |
format | Online Article Text |
id | pubmed-3541331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-35413312013-01-18 Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors Mejia, Jonathan Haberman, Adam Commun Integr Biol Article Addendum Neurons have unique challenges relative to other cell types. Unlike most other cells, neurons must remain healthy and functional throughout the lifespan of an animal. Premature neuronal loss underlies many age-related neurodegenerative diseases, including Alzheimer and Parkinson Diseases. Despite previous research aimed at understanding the mechanisms of age-related neurodegenerative diseases, little is known about the mechanisms that allow neurons to remain functional for the lifetime of a healthy animal. Understanding these cellular and biochemical processes is essential to promote healthful aging and reduce the severity of neurodegenerative disease. Here we discuss our recent identification of neuron-specific proteins that regulate endosome fusion events and the role of endosomes in maintaining healthy neurons. Landes Bioscience 2012-11-01 /pmc/articles/PMC3541331/ /pubmed/23740166 http://dx.doi.org/10.4161/cib.21434 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Article Addendum Mejia, Jonathan Haberman, Adam Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors |
title | Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors |
title_full | Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors |
title_fullStr | Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors |
title_full_unstemmed | Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors |
title_short | Neuronal synaptobrevin promotes longevity in Drosophila photoreceptors |
title_sort | neuronal synaptobrevin promotes longevity in drosophila photoreceptors |
topic | Article Addendum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541331/ https://www.ncbi.nlm.nih.gov/pubmed/23740166 http://dx.doi.org/10.4161/cib.21434 |
work_keys_str_mv | AT mejiajonathan neuronalsynaptobrevinpromoteslongevityindrosophilaphotoreceptors AT habermanadam neuronalsynaptobrevinpromoteslongevityindrosophilaphotoreceptors |