Cargando…

The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat

BACKGROUND: Mefloquine is an anti-malarial drug that can have neurological side effects. This study examines how mefloquine (MF) influences central nervous control of autonomic and respiratory systems using the arterially perfused working heart brainstem preparation (WHBP) of the rat. Recordings of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lall, Varinder K, Dutschmann, Mathias, Deuchars, Jim, Deuchars, Susan A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541349/ https://www.ncbi.nlm.nih.gov/pubmed/23241425 http://dx.doi.org/10.1186/1423-0127-19-103

Ejemplares similares

Mechanisms underpinning sympathetic nervous activity and its modulation using transcutaneous vagus nerve stimulation
por: Deuchars, Susan A., et al.
Publicado: (2017)

Neck muscle afferents influence oromotor and cardiorespiratory brainstem neural circuits
por: Edwards, I. J., et al.
Publicado: (2014)

Physiologic regulation of heart rate and blood pressure involves connexin 36–containing gap junctions
por: Lall, Varinder K., et al.
Publicado: (2017)

GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord()
por: Corns, Laura F., et al.
Publicado: (2013)

Co-expression of GAD67 and choline acetyltransferase in neurons in the mouse spinal cord: A focus on lamina X
por: Gotts, Jittima, et al.
Publicado: (2016)

GABA(B) Mediated Regulation of Sympathetic Preganglionic Neurons: Pre- and Postsynaptic Sites of Action
por: Wang, LiHua, et al.
Publicado: (2010)

Effects of transcutaneous vagus nerve stimulation in individuals aged 55 years or above: potential benefits of daily stimulation
por: Bretherton, Beatrice, et al.
Publicado: (2019)

Kv3 Channels Contribute to the Excitability of Subpopulations of Spinal Cord Neurons in Lamina VII
por: Mullen, Pierce N., et al.
Publicado: (2022)

Co-expression of GAD67 and choline acetyltransferase reveals a novel neuronal phenotype in the mouse medulla oblongata
por: Gotts, Jittima, et al.
Publicado: (2015)

Mediation of Cardiac Macrophage Activity via Auricular Vagal Nerve Stimulation Ameliorates Cardiac Ischemia/Reperfusion Injury
por: Chung, Chee Hooi, et al.
Publicado: (2020)

Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children
por: Sowunmi, Akintunde, et al.
Publicado: (2009)

Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years
por: Paton, Julian F. R., et al.
Publicado: (2022)

Cholinergic Enhancement of Cell Proliferation in the Postnatal Neurogenic Niche of the Mammalian Spinal Cord
por: Corns, Laura F., et al.
Publicado: (2015)

Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice
por: Pierce, M.L., et al.
Publicado: (2010)

Graded spikes differentially signal neurotransmitter input in cerebrospinal fluid contacting neurons of the mouse spinal cord
por: Johnson, Emily, et al.
Publicado: (2022)

Brainstem sources of cardiac vagal tone and respiratory sinus arrhythmia
por: Farmer, David G.S., et al.
Publicado: (2016)

Treatment of Suspected Hyper-Reactive Malarial Splenomegaly (HMS) in Pregnancy with Mefloquine
por: Jaroensuk, Juthamas, et al.
Publicado: (2014)

Drug repurposing applied: Activity of the anti-malarial mefloquine against Echinococcus multilocularis
por: Lundström-Stadelmann, Britta, et al.
Publicado: (2020)

Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation
por: Dhingra, Rishi R., et al.
Publicado: (2019)

Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice
por: Chapman, R. J., et al.
Publicado: (2012)

Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus
por: John, Danielle, et al.
Publicado: (2015)

Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis
por: Rufener, Reto, et al.
Publicado: (2018)

Dynamic remodelling of synapses can occur in the absence of the parent cell body
por: Bettini, Natalia L, et al.
Publicado: (2007)

Inhibition of mitochondrial fission and iNOS in the dorsal vagal complex protects from overeating and weight gain
por: Patel, Bianca, et al.
Publicado: (2020)

Fiber optical imaging of astroglial calcium signaling in the respiratory network in the working heart brainstem preparation
por: Tacke, Charlotte, et al.
Publicado: (2023)

Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria
por: Gutman, Julie, et al.
Publicado: (2009)

Mefloquine: Psychosis: case report
Publicado: (2022)

Mefloquine-associated dizziness, diplopia, and central serous chorioretinopathy: a case report
por: Jain, Manish, et al.
Publicado: (2016)

Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria
por: Saeheng, Teerachat, et al.
Publicado: (2023)

The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro
por: Dow, Geoffrey S, et al.
Publicado: (2003)

Mefloquine for preventing malaria in pregnant women
por: González, Raquel, et al.
Publicado: (2018)

Mefloquine for preventing malaria in pregnant women
por: González, Raquel, et al.
Publicado: (2018)

Misclassification and Bias in Military Studies of Mefloquine
por: Lee Nevin, Remington
Publicado: (2017)

Development of Resistance Against Mefloquine Prophylaxis in Peace-Keeping Forces in the Central African Republic
por: Malik, Javaria Arshad, et al.
Publicado: (2020)

Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria
por: Congpuong, Kanungnit, et al.
Publicado: (2010)

A retrospective analysis of the protective efficacy of tafenoquine and mefloquine as prophylactic anti-malarials in non-immune individuals during deployment to a malaria-endemic area
por: Dow, Geoffrey S, et al.
Publicado: (2014)

Praziquantel, Mefloquine-Praziquantel, and Mefloquine-Artesunate-Praziquantel against Schistosoma haematobium: A Randomized, Exploratory, Open-Label Trial
por: Keiser, Jennifer, et al.
Publicado: (2014)

Idiosyncratic quinoline central nervous system toxicity: Historical insights into the chronic neurological sequelae of mefloquine()
por: Nevin, Remington L.
Publicado: (2014)

Reduced brainstem functional connectivity in patients with peripheral autonomic failure
por: Baker, Jacquie, et al.
Publicado: (2019)

Mefloquine—An Aminoalcohol with Promising Antischistosomal Properties in Mice
por: Keiser, Jennifer, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_58a5rsv502afjo3q174g9mn95h