Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response

Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes (SSRBCs) but not normal RBCs (NLRBCs) to selectively target hypoxic tumor...

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Detalles Bibliográficos
Autores principales: Terman, David S., Viglianti, Benjamin L., Zennadi, Rahima, Fels, Diane, Boruta, Richard J., Yuan, Hong, Dreher, Mathew R., Grant, Gerald, Rabbani, Zahid N., Moon, Ejung, Lan, Lan, Eble, Joseph, Cao, Yiting, Sorg, Brian, Ashcraft, Kathleen, Palmer, Greg, Telen, Marilyn J., Dewhirst, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541382/
https://www.ncbi.nlm.nih.gov/pubmed/23326340
http://dx.doi.org/10.1371/journal.pone.0052543

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