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Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials

Objectives. To assess the current clinical evidence of Banxia Baizhu Tianma Decoction (BBTD) for essential hypertension (EH). Search Strategy. Electronic databases were searched until July 2012. Inclusion Criteria. We included randomized clinical trials testing BBTD against placebo, antihypertensive...

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Detalles Bibliográficos
Autores principales: Xiong, Xingjiang, Yang, Xiaochen, Liu, Wei, Feng, Bo, Ma, Jizheng, Du, Xinliang, Wang, Pengqian, Chu, Fuyong, Li, Jun, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541533/
https://www.ncbi.nlm.nih.gov/pubmed/23320025
http://dx.doi.org/10.1155/2012/271462
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author Xiong, Xingjiang
Yang, Xiaochen
Liu, Wei
Feng, Bo
Ma, Jizheng
Du, Xinliang
Wang, Pengqian
Chu, Fuyong
Li, Jun
Wang, Jie
author_facet Xiong, Xingjiang
Yang, Xiaochen
Liu, Wei
Feng, Bo
Ma, Jizheng
Du, Xinliang
Wang, Pengqian
Chu, Fuyong
Li, Jun
Wang, Jie
author_sort Xiong, Xingjiang
collection PubMed
description Objectives. To assess the current clinical evidence of Banxia Baizhu Tianma Decoction (BBTD) for essential hypertension (EH). Search Strategy. Electronic databases were searched until July 2012. Inclusion Criteria. We included randomized clinical trials testing BBTD against placebo, antihypertensive drugs, or combined with antihypertensive drugs against antihypertensive drugs. Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results. 16 randomized trials were included. Methodological quality of the included trials was evaluated as generally low. 2 trials compared prescriptions based on BBTD using alone with antihypertensive drugs. Meta-analysis showed no significant effect of modified BBTD compared with captopril in systolic blood pressure (MD: −0.75 (−5.77, 4.27); P = 0.77) and diastolic blood pressure (MD: −0.75 (−2.89, 1.39); P = 0.49). 14 trials compared the combination of BBTD or modified BBTD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed there are significant beneficial effect on systolic blood pressure in the combination group compare to the antihypertensive drugs (MD: −4.33 (−8.44, −0.22); P = 0.04). The safety of BBTD is uncertain. Conclusions. There is encouraging evidence of BBTD for lowering SBP, but evidence remains weak. Rigorously designed trials are warranted to confirm these results.
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spelling pubmed-35415332013-01-14 Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials Xiong, Xingjiang Yang, Xiaochen Liu, Wei Feng, Bo Ma, Jizheng Du, Xinliang Wang, Pengqian Chu, Fuyong Li, Jun Wang, Jie Evid Based Complement Alternat Med Research Article Objectives. To assess the current clinical evidence of Banxia Baizhu Tianma Decoction (BBTD) for essential hypertension (EH). Search Strategy. Electronic databases were searched until July 2012. Inclusion Criteria. We included randomized clinical trials testing BBTD against placebo, antihypertensive drugs, or combined with antihypertensive drugs against antihypertensive drugs. Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results. 16 randomized trials were included. Methodological quality of the included trials was evaluated as generally low. 2 trials compared prescriptions based on BBTD using alone with antihypertensive drugs. Meta-analysis showed no significant effect of modified BBTD compared with captopril in systolic blood pressure (MD: −0.75 (−5.77, 4.27); P = 0.77) and diastolic blood pressure (MD: −0.75 (−2.89, 1.39); P = 0.49). 14 trials compared the combination of BBTD or modified BBTD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed there are significant beneficial effect on systolic blood pressure in the combination group compare to the antihypertensive drugs (MD: −4.33 (−8.44, −0.22); P = 0.04). The safety of BBTD is uncertain. Conclusions. There is encouraging evidence of BBTD for lowering SBP, but evidence remains weak. Rigorously designed trials are warranted to confirm these results. Hindawi Publishing Corporation 2012 2012-12-20 /pmc/articles/PMC3541533/ /pubmed/23320025 http://dx.doi.org/10.1155/2012/271462 Text en Copyright © 2012 Xingjiang Xiong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiong, Xingjiang
Yang, Xiaochen
Liu, Wei
Feng, Bo
Ma, Jizheng
Du, Xinliang
Wang, Pengqian
Chu, Fuyong
Li, Jun
Wang, Jie
Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials
title Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials
title_full Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials
title_fullStr Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials
title_full_unstemmed Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials
title_short Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials
title_sort banxia baizhu tianma decoction for essential hypertension: a systematic review of randomized controlled trials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541533/
https://www.ncbi.nlm.nih.gov/pubmed/23320025
http://dx.doi.org/10.1155/2012/271462
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