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A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extra...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541551/ https://www.ncbi.nlm.nih.gov/pubmed/23326738 http://dx.doi.org/10.1155/2012/948351 |
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author | Nayak, Lalitha Schmaier, Alvin H. |
author_facet | Nayak, Lalitha Schmaier, Alvin H. |
author_sort | Nayak, Lalitha |
collection | PubMed |
description | The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4–6 weeks after starting tamoxifen. Investigations were consistent with an acquired platelet storage pool disorder. Repeat platelet function analysis was normal, performed 3 months after discontinuation of tamoxifen. We present a previously clinically unreported effect of tamoxifen on platelet function. |
format | Online Article Text |
id | pubmed-3541551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35415512013-01-16 A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy Nayak, Lalitha Schmaier, Alvin H. Case Rep Hematol Case Report The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4–6 weeks after starting tamoxifen. Investigations were consistent with an acquired platelet storage pool disorder. Repeat platelet function analysis was normal, performed 3 months after discontinuation of tamoxifen. We present a previously clinically unreported effect of tamoxifen on platelet function. Hindawi Publishing Corporation 2012 2012-12-26 /pmc/articles/PMC3541551/ /pubmed/23326738 http://dx.doi.org/10.1155/2012/948351 Text en Copyright © 2012 L. Nayak and A. H. Schmaier. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Nayak, Lalitha Schmaier, Alvin H. A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy |
title | A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy |
title_full | A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy |
title_fullStr | A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy |
title_full_unstemmed | A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy |
title_short | A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy |
title_sort | platelet acquired storage pool disorder associated with tamoxifen therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541551/ https://www.ncbi.nlm.nih.gov/pubmed/23326738 http://dx.doi.org/10.1155/2012/948351 |
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