Cargando…

A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy

The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extra...

Descripción completa

Detalles Bibliográficos
Autores principales: Nayak, Lalitha, Schmaier, Alvin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541551/
https://www.ncbi.nlm.nih.gov/pubmed/23326738
http://dx.doi.org/10.1155/2012/948351
_version_ 1782255375695740928
author Nayak, Lalitha
Schmaier, Alvin H.
author_facet Nayak, Lalitha
Schmaier, Alvin H.
author_sort Nayak, Lalitha
collection PubMed
description The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4–6 weeks after starting tamoxifen. Investigations were consistent with an acquired platelet storage pool disorder. Repeat platelet function analysis was normal, performed 3 months after discontinuation of tamoxifen. We present a previously clinically unreported effect of tamoxifen on platelet function.
format Online
Article
Text
id pubmed-3541551
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35415512013-01-16 A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy Nayak, Lalitha Schmaier, Alvin H. Case Rep Hematol Case Report The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4–6 weeks after starting tamoxifen. Investigations were consistent with an acquired platelet storage pool disorder. Repeat platelet function analysis was normal, performed 3 months after discontinuation of tamoxifen. We present a previously clinically unreported effect of tamoxifen on platelet function. Hindawi Publishing Corporation 2012 2012-12-26 /pmc/articles/PMC3541551/ /pubmed/23326738 http://dx.doi.org/10.1155/2012/948351 Text en Copyright © 2012 L. Nayak and A. H. Schmaier. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nayak, Lalitha
Schmaier, Alvin H.
A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_full A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_fullStr A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_full_unstemmed A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_short A Platelet Acquired Storage Pool Disorder Associated with Tamoxifen Therapy
title_sort platelet acquired storage pool disorder associated with tamoxifen therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541551/
https://www.ncbi.nlm.nih.gov/pubmed/23326738
http://dx.doi.org/10.1155/2012/948351
work_keys_str_mv AT nayaklalitha aplateletacquiredstoragepooldisorderassociatedwithtamoxifentherapy
AT schmaieralvinh aplateletacquiredstoragepooldisorderassociatedwithtamoxifentherapy
AT nayaklalitha plateletacquiredstoragepooldisorderassociatedwithtamoxifentherapy
AT schmaieralvinh plateletacquiredstoragepooldisorderassociatedwithtamoxifentherapy