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Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo

BACKGROUND: Cyclic GMP (cGMP) signaling attenuates cardiac remodeling, but it is unclear which cGMP effectors mediate these effects and thus might serve as novel therapeutic targets. Therefore, we tested whether the cGMP downstream effector, cGMP-dependent protein kinase G Iα (PKGIα), attenuates pre...

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Detalles Bibliográficos
Autores principales:	Blanton, Robert M., Takimoto, Eiki, Lane, Angela M., Aronovitz, Mark, Piotrowski, Robert, Karas, Richard H., Kass, David A., Mendelsohn, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541610/ https://www.ncbi.nlm.nih.gov/pubmed/23316302 http://dx.doi.org/10.1161/JAHA.112.003731

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