Inhibition of Apoptosis Signal–Regulating Kinase 1 Reduces Myocardial Ischemia–Reperfusion Injury in the Mouse

BACKGROUND: Despite the clear advantages of reperfusion in acute myocardial infarction, part of the myocardium is injured during reperfusion by reactive oxygen species. Reactive oxygen species activate apoptosis signal–regulating kinase-1, a key mediator in cell death. We hypothesized that inhibitio...

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Detalles Bibliográficos
Autores principales: Toldo, Stefano, Breckenridge, David G., Mezzaroma, Eleonora, Tassell, Benjamin W., Shryock, John, Kannan, Harsha, Phan, Dillon, Budas, Grant, Farkas, Daniela, Lesnefsky, Edward, Voelkel, Norbert, Abbate, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541620/
https://www.ncbi.nlm.nih.gov/pubmed/23316291
http://dx.doi.org/10.1161/JAHA.112.002360

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