Arterial Retention of Remnant Lipoproteins Ex Vivo Is Increased in Insulin Resistance Because of Increased Arterial Biglycan and Production of Cholesterol-Rich Atherogenic Particles That Can Be Improved by Ezetimibe in the JCR:LA-cp Rat

BACKGROUND: Literature supports the “response-to-retention” hypothesis—that during insulin resistance, impaired metabolism of remnant lipoproteins can contribute to accelerated cardiovascular disease progression. We used the JCR:LA-cp rat model of metabolic syndrome (MetS) to determine the extent of...

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Detalles Bibliográficos
Autores principales: Mangat, Rabban, Warnakula, Samantha, Borthwick, Faye, Hassanali, Zahra, Uwiera, Richard R.E., Russell, James C., Cheeseman, Christopher I., Vine, Donna F., Proctor, Spencer D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541624/
https://www.ncbi.nlm.nih.gov/pubmed/23316299
http://dx.doi.org/10.1161/JAHA.112.003434

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