Cargando…

After TGN1412: Recent developments in cytokine release assays

The failure of regulatory science to keep pace with and support the development of new biological medicines was very publically highlighted in March 2006 when the first-in-man Phase I clinical trial of the immunomodulatory CD28-specific monoclonal antibody (mAb) TGN1412 ended in disaster when all si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stebbings, R., Eastwood, D., Poole, S., Thorpe, R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Informa Healthcare 2013
Materias:	Paper from the 20th Summerschool in Immunotoxicology, Beaune, France, Sept. 26–28, 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541671/ https://www.ncbi.nlm.nih.gov/pubmed/22967038 http://dx.doi.org/10.3109/1547691X.2012.711783

Ejemplares similares

Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release
por: Eastwood, David, et al.
Publicado: (2013)

Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials — Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm
por: Vessillier, S., et al.
Publicado: (2015)

The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers—Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility
por: Gradin, Robin, et al.
Publicado: (2020)

TGN1412: From Discovery to Disaster
por: Attarwala, H
Publicado: (2010)

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha
por: Lu, Jingtao, et al.
Publicado: (2012)

Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis
por: Sernoskie, Samantha Christine, et al.
Publicado: (2021)

TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model
por: Weißmüller, Sabrina, et al.
Publicado: (2016)

Influence of deoxynivalenol-contaminated feed on the immune response of pigs after PRRSV vaccination and infection
por: Pierron, Alix, et al.
Publicado: (2023)

Targets and Intracellular Signaling Mechanisms for Deoxynivalenol-Induced Ribosomal RNA Cleavage
por: He, Kaiyu, et al.
Publicado: (2012)

Immunological impact of graphene oxide sheets in the abdominal cavity is governed by surface reactivity
por: Rodrigues, Artur Filipe, et al.
Publicado: (2018)

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac
por: Selvaraj, Saravanakumar, et al.
Publicado: (2020)

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells
por: Chen, I-Ling, et al.
Publicado: (2020)

Characterization of the Class I MHC Peptidome Resulting From DNCB Exposure of HaCaT Cells
por: Bailey, Alistair, et al.
Publicado: (2020)

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01
por: Ogese, Monday O, et al.
Publicado: (2021)

Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs
por: Madar-Balakirski, Noa, et al.
Publicado: (2022)

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages
por: Hiéronimus, Léa, et al.
Publicado: (2021)

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity
por: Hammond, Sean, et al.
Publicado: (2021)

Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque
por: Dai, Xuedong, et al.
Publicado: (2022)

rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits
por: Rosner, Amir, et al.
Publicado: (2022)

Electronic cigarette vapor exposure exaggerates the pro-inflammatory response during influenza A viral infection in human distal airway epithelium
por: Schaunaman, Niccolette, et al.
Publicado: (2022)

Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case–control study
por: Nakajima, Tamie, et al.
Publicado: (2022)

Quantifying the impact of PFOA exposure on B-cell development and antibody production
por: Taylor, Krystal D, et al.
Publicado: (2023)

Role of miR-24-3p and miR-146a-5p in dendritic cells’ maturation process induced by contact sensitizers
por: Galbiati, Valentina, et al.
Publicado: (2023)

Development of an in chemico high-throughput screening method for the identification of skin sensitization potential
por: Ferreira, Isabel, et al.
Publicado: (2023)

Applicability of the DPRA on mixture testing: challenges and opportunities
por: Marcelis, Quinten, et al.
Publicado: (2023)

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
por: Ali, Serat-E, et al.
Publicado: (2023)

Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm
por: Panoskaltsis, Nicki, et al.
Publicado: (2020)

The Effect of Body Mass Index on Presentation of COVID-19 amongst Heart Transplant Recipients: A Multi-Institutional Study
por: Iyengar, A., et al.
Publicado: (2021)

UTILIZAÇÃO DA ARTE RELACIONADA A COVID‐19 COMO ESTRATÉGIA EDUCATIVA NO CURSO DE MEDICINA
por: Medeiros, Melissa Soares, et al.
Publicado: (2021)

Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist
por: Thaventhiran, Thilipan, et al.
Publicado: (2014)

Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells
por: McCarthy, Neil E., et al.
Publicado: (2020)

Revisiting CD28 Superagonist TGN1412 as Potential Therapeutic for Pediatric B Cell Leukemia: A Review
por: Brown, Katelyn E.
Publicado: (2018)

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice
por: Prakash, Thazha P., et al.
Publicado: (2014)

Transtibial Tunnel Placement in Posterior Cruciate Ligament Reconstruction: How It Relates to the Anatomic Footprint
por: Tompkins, Marc, et al.
Publicado: (2014)

Rapid Virtualization of a Heart Function Clinic in Response to the COVID-19 Pandemic
por: Linghorne, M., et al.
Publicado: (2021)

Valeur pronostique du KL-6 initial (Krebs von den Lungen 6) au cours de la pneumopathie à SARS-CoV-2
por: Letellier, A., et al.
Publicado: (2022)

Impact d'une campagne de vaccination COVID-19 en population carcérale
por: Diallo, K., et al.
Publicado: (2022)

Gestion d’un cluster de COVID-19 : expérience d’un CH
por: Tolsma, V., et al.
Publicado: (2020)

Impact of specialty pharmacist integration on time to medication access for pimavanserin
por: Livezey, Sabrina, et al.
Publicado: (2019)

Analyse rétrospective des expositions enregistrée par les centres antipoison français pendant la première vague de COVID-19
por: Descatha, Alexis, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dvcehlqddg9knmgead8omke4er