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Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report
The concurrence of amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) is extremely rare. We reported the case of a 33-year-old woman with a past history of paresthesias at the right hand, who developed progressive quadriparesis with muscular atrophy of limbs and, finally, bulbar signs a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541770/ https://www.ncbi.nlm.nih.gov/pubmed/23326272 http://dx.doi.org/10.1155/2012/324685 |
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author | Trojsi, Francesca Sagnelli, Anna Cirillo, Giovanni Piccirillo, Giovanni Femiano, Cinzia Izzo, Francesco Monsurrò, Maria Rosaria Tedeschi, Gioacchino |
author_facet | Trojsi, Francesca Sagnelli, Anna Cirillo, Giovanni Piccirillo, Giovanni Femiano, Cinzia Izzo, Francesco Monsurrò, Maria Rosaria Tedeschi, Gioacchino |
author_sort | Trojsi, Francesca |
collection | PubMed |
description | The concurrence of amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) is extremely rare. We reported the case of a 33-year-old woman with a past history of paresthesias at the right hand, who developed progressive quadriparesis with muscular atrophy of limbs and, finally, bulbar signs and dyspnea. Clinical and neurophysiologic investigations revealed upper and lower motor neuron signs in the bulbar region and extremities, suggesting the diagnosis of ALS. Moreover, magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) analysis demonstrated 3 periventricular and juxtacortical lesions, hyperintense in T2 and FLAIR sequences, and 3 liquoral immunoglobulin G (IgG) oligoclonal bands, consistent with diagnosis of primary progressive MS (PPMS). This unusual overlap of ALS and MS leads to the discussion of a hypothetical common pathological process of immunological dysfunction in these two disorders, although the role of immune response in ALS remains ambivalent and unclear. |
format | Online Article Text |
id | pubmed-3541770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35417702013-01-16 Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report Trojsi, Francesca Sagnelli, Anna Cirillo, Giovanni Piccirillo, Giovanni Femiano, Cinzia Izzo, Francesco Monsurrò, Maria Rosaria Tedeschi, Gioacchino Case Rep Med Case Report The concurrence of amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) is extremely rare. We reported the case of a 33-year-old woman with a past history of paresthesias at the right hand, who developed progressive quadriparesis with muscular atrophy of limbs and, finally, bulbar signs and dyspnea. Clinical and neurophysiologic investigations revealed upper and lower motor neuron signs in the bulbar region and extremities, suggesting the diagnosis of ALS. Moreover, magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) analysis demonstrated 3 periventricular and juxtacortical lesions, hyperintense in T2 and FLAIR sequences, and 3 liquoral immunoglobulin G (IgG) oligoclonal bands, consistent with diagnosis of primary progressive MS (PPMS). This unusual overlap of ALS and MS leads to the discussion of a hypothetical common pathological process of immunological dysfunction in these two disorders, although the role of immune response in ALS remains ambivalent and unclear. Hindawi Publishing Corporation 2012 2012-12-24 /pmc/articles/PMC3541770/ /pubmed/23326272 http://dx.doi.org/10.1155/2012/324685 Text en Copyright © 2012 Francesca Trojsi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Trojsi, Francesca Sagnelli, Anna Cirillo, Giovanni Piccirillo, Giovanni Femiano, Cinzia Izzo, Francesco Monsurrò, Maria Rosaria Tedeschi, Gioacchino Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report |
title | Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report |
title_full | Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report |
title_fullStr | Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report |
title_full_unstemmed | Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report |
title_short | Amyotrophic Lateral Sclerosis and Multiple Sclerosis Overlap: A Case Report |
title_sort | amyotrophic lateral sclerosis and multiple sclerosis overlap: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541770/ https://www.ncbi.nlm.nih.gov/pubmed/23326272 http://dx.doi.org/10.1155/2012/324685 |
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