Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier–dependent pathway

Small heat shock proteins (sHsps) bind destabilized proteins during cell stress and disease, but their physiological functions are less clear. We evaluated the impact of Hsp27, an sHsp expressed in airway epithelial cells, on the common protein misfolding mutant that is responsible for most cystic f...

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Detalles Bibliográficos
Autores principales: Ahner, Annette, Gong, Xiaoyan, Schmidt, Bela Z., Peters, Kathryn W., Rabeh, Wael M., Thibodeau, Patrick H., Lukacs, Gergely L., Frizzell, Raymond A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541966/
https://www.ncbi.nlm.nih.gov/pubmed/23155000
http://dx.doi.org/10.1091/mbc.E12-09-0678

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