Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate

Streptococcus suis (S. suis) infection is considered to be a major problem in the swine industry worldwide. Based on the capsular type, 33 serotypes of S. suis have been described, with serotype 2 (SS2) being the most frequently isolated from diseased piglets. Little is known, however, about the pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Fang, Zhang, Wei, Lu, Chengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542266/
https://www.ncbi.nlm.nih.gov/pubmed/23326601
http://dx.doi.org/10.1371/journal.pone.0054227
_version_ 1782255481125863424
author Tang, Fang
Zhang, Wei
Lu, Chengping
author_facet Tang, Fang
Zhang, Wei
Lu, Chengping
author_sort Tang, Fang
collection PubMed
description Streptococcus suis (S. suis) infection is considered to be a major problem in the swine industry worldwide. Based on the capsular type, 33 serotypes of S. suis have been described, with serotype 2 (SS2) being the most frequently isolated from diseased piglets. Little is known, however, about the pathogenesis and virulence factors of S. suis. Research on bacteriophages highlights a new area in S. suis research. A S. suis serotype 2 bacteriophage, designated SMP, has been previously isolated in our laboratory. Here, we selected a lysogenic isolate in which the SMP phage was integrated into the chromosome of strain SS2-4. Compared to the wild-type isolate, the lysogenic strain showed increased mortality in zebra fish. Moreover the sensitivity of the lysogenic strain to lysozyme was seven times higher than that of the wild-type.
format Online
Article
Text
id pubmed-3542266
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-35422662013-01-16 Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate Tang, Fang Zhang, Wei Lu, Chengping PLoS One Research Article Streptococcus suis (S. suis) infection is considered to be a major problem in the swine industry worldwide. Based on the capsular type, 33 serotypes of S. suis have been described, with serotype 2 (SS2) being the most frequently isolated from diseased piglets. Little is known, however, about the pathogenesis and virulence factors of S. suis. Research on bacteriophages highlights a new area in S. suis research. A S. suis serotype 2 bacteriophage, designated SMP, has been previously isolated in our laboratory. Here, we selected a lysogenic isolate in which the SMP phage was integrated into the chromosome of strain SS2-4. Compared to the wild-type isolate, the lysogenic strain showed increased mortality in zebra fish. Moreover the sensitivity of the lysogenic strain to lysozyme was seven times higher than that of the wild-type. Public Library of Science 2013-01-10 /pmc/articles/PMC3542266/ /pubmed/23326601 http://dx.doi.org/10.1371/journal.pone.0054227 Text en © 2013 Tang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tang, Fang
Zhang, Wei
Lu, Chengping
Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate
title Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate
title_full Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate
title_fullStr Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate
title_full_unstemmed Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate
title_short Lysogenic Streptococcus suis Isolate SS2-4 Containing Prophage SMP Showed Increased Mortality in Zebra Fish Compared to the Wild-Type Isolate
title_sort lysogenic streptococcus suis isolate ss2-4 containing prophage smp showed increased mortality in zebra fish compared to the wild-type isolate
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542266/
https://www.ncbi.nlm.nih.gov/pubmed/23326601
http://dx.doi.org/10.1371/journal.pone.0054227
work_keys_str_mv AT tangfang lysogenicstreptococcussuisisolatess24containingprophagesmpshowedincreasedmortalityinzebrafishcomparedtothewildtypeisolate
AT zhangwei lysogenicstreptococcussuisisolatess24containingprophagesmpshowedincreasedmortalityinzebrafishcomparedtothewildtypeisolate
AT luchengping lysogenicstreptococcussuisisolatess24containingprophagesmpshowedincreasedmortalityinzebrafishcomparedtothewildtypeisolate

Ejemplares similares