Histone Deacetylase Inhibition Decreases Cholesterol Levels in Neuronal Cells by Modulating Key Genes in Cholesterol Synthesis, Uptake and Efflux

Cholesterol is an essential component of the central nervous system and increasing evidence suggests an association between brain cholesterol metabolism dysfunction and the onset of neurodegenerative disorders. Interestingly, histone deacetylase inhibitors (HDACi) such as trichostatin A (TSA) are em...

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Detalles Bibliográficos
Autores principales: Nunes, Maria João, Moutinho, Miguel, Gama, Maria João, Rodrigues, Cecília M. P., Rodrigues, Elsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542332/
https://www.ncbi.nlm.nih.gov/pubmed/23326422
http://dx.doi.org/10.1371/journal.pone.0053394

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