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Changes of subtests of Wechsler Memory Scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine

INTRODUCTION: Subclinical hypothyroidism has been reported to be associated with disturbed cognitive function. In this study, changes of subtests of the Wechsler Memory Scale and memory quotient were investigated in subjects with subclinical hypothyroidism following treatment with levothyroxine. The...

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Autores principales: Aghili, Rokhsareh, Khamseh, Mohammad E., Malek, Mojtaba, Hadian, Ali, Baradaran, Hamid R., Najafi, Laily, Emami, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542502/
https://www.ncbi.nlm.nih.gov/pubmed/23319987
http://dx.doi.org/10.5114/aoms.2012.32423
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author Aghili, Rokhsareh
Khamseh, Mohammad E.
Malek, Mojtaba
Hadian, Ali
Baradaran, Hamid R.
Najafi, Laily
Emami, Zahra
author_facet Aghili, Rokhsareh
Khamseh, Mohammad E.
Malek, Mojtaba
Hadian, Ali
Baradaran, Hamid R.
Najafi, Laily
Emami, Zahra
author_sort Aghili, Rokhsareh
collection PubMed
description INTRODUCTION: Subclinical hypothyroidism has been reported to be associated with disturbed cognitive function. In this study, changes of subtests of the Wechsler Memory Scale and memory quotient were investigated in subjects with subclinical hypothyroidism following treatment with levothyroxine. The aim of the study was a randomized double blind placebo-controlled clinical trial. MATERIAL AND METHODS: Sixty subjects (51 females and 9 males) with subclinical hypothyroidism were enrolled. Memory quotient was evaluated at the beginning of the study and three months after enrollment, using Wechsler's memory test. Subclinical hypothyroidism was defined as serum TSH level between 4.5 mU/l and 10 mU/l in the presence of normal free-T4 (0.8-2 ng/dl) and positive anti-TPO-Ab. The intervention and control groups received levothyroxine and placebo respectively for 3 months. Re-evaluation was done using the Wechsler Memory Scale at the end of the study. RESULTS: The mean age was 34 ±10 years, mean TSH level was 8.25 ±3.64 muIU/l. Memory quotient was similar in both groups at the beginning of the study: 105.70 ±2.1 in intervention group vs. 105.87 ±2.1 in control group (p = 0.89). At the end of the study, the memory quotient rose by 9.3 points in the intervention group and by 3.23 in the controls (p = 0.002). Analysis of the scores of Wechsler Memory subtests in the intervention group indicated significant improvement of mental control (p = 0.002), logical memory (p < 0.001), associate learning (p = 0.014), age corrected score (p = 0.002), and memory quotient (p < 0.001). CONCLUSIONS: This study showed the efficacy of levothyroxine for cognitive function of subjects with subclinical hypothyroidism.
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spelling pubmed-35425022013-01-14 Changes of subtests of Wechsler Memory Scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine Aghili, Rokhsareh Khamseh, Mohammad E. Malek, Mojtaba Hadian, Ali Baradaran, Hamid R. Najafi, Laily Emami, Zahra Arch Med Sci Clinical Research INTRODUCTION: Subclinical hypothyroidism has been reported to be associated with disturbed cognitive function. In this study, changes of subtests of the Wechsler Memory Scale and memory quotient were investigated in subjects with subclinical hypothyroidism following treatment with levothyroxine. The aim of the study was a randomized double blind placebo-controlled clinical trial. MATERIAL AND METHODS: Sixty subjects (51 females and 9 males) with subclinical hypothyroidism were enrolled. Memory quotient was evaluated at the beginning of the study and three months after enrollment, using Wechsler's memory test. Subclinical hypothyroidism was defined as serum TSH level between 4.5 mU/l and 10 mU/l in the presence of normal free-T4 (0.8-2 ng/dl) and positive anti-TPO-Ab. The intervention and control groups received levothyroxine and placebo respectively for 3 months. Re-evaluation was done using the Wechsler Memory Scale at the end of the study. RESULTS: The mean age was 34 ±10 years, mean TSH level was 8.25 ±3.64 muIU/l. Memory quotient was similar in both groups at the beginning of the study: 105.70 ±2.1 in intervention group vs. 105.87 ±2.1 in control group (p = 0.89). At the end of the study, the memory quotient rose by 9.3 points in the intervention group and by 3.23 in the controls (p = 0.002). Analysis of the scores of Wechsler Memory subtests in the intervention group indicated significant improvement of mental control (p = 0.002), logical memory (p < 0.001), associate learning (p = 0.014), age corrected score (p = 0.002), and memory quotient (p < 0.001). CONCLUSIONS: This study showed the efficacy of levothyroxine for cognitive function of subjects with subclinical hypothyroidism. Termedia Publishing House 2012-12-19 2012-12-20 /pmc/articles/PMC3542502/ /pubmed/23319987 http://dx.doi.org/10.5114/aoms.2012.32423 Text en Copyright © 2012 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Aghili, Rokhsareh
Khamseh, Mohammad E.
Malek, Mojtaba
Hadian, Ali
Baradaran, Hamid R.
Najafi, Laily
Emami, Zahra
Changes of subtests of Wechsler Memory Scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine
title Changes of subtests of Wechsler Memory Scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine
title_full Changes of subtests of Wechsler Memory Scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine
title_fullStr Changes of subtests of Wechsler Memory Scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine
title_full_unstemmed Changes of subtests of Wechsler Memory Scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine
title_short Changes of subtests of Wechsler Memory Scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine
title_sort changes of subtests of wechsler memory scale and cognitive function in subjects with subclinical hypothyroidism following treatment with levothyroxine
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542502/
https://www.ncbi.nlm.nih.gov/pubmed/23319987
http://dx.doi.org/10.5114/aoms.2012.32423
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