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Current advances in using neurotrophic factors to treat neurodegenerative disorders

Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system. Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of...

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Detalles Bibliográficos
Autores principales: Weissmiller, April M, Wu, Chengbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542569/
https://www.ncbi.nlm.nih.gov/pubmed/23210531
http://dx.doi.org/10.1186/2047-9158-1-14
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author Weissmiller, April M
Wu, Chengbiao
author_facet Weissmiller, April M
Wu, Chengbiao
author_sort Weissmiller, April M
collection PubMed
description Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system. Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative disorders. However, significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic arena. This article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments.
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spelling pubmed-35425692013-01-11 Current advances in using neurotrophic factors to treat neurodegenerative disorders Weissmiller, April M Wu, Chengbiao Transl Neurodegener Review Neurotrophic factors are best known for their roles in both development and continued maintenance of the nervous system. Their strong potential to elicit pro-survival and pro-functional responses in neurons of the peripheral and central nervous system make them good drug candidates for treatment of a multitude of neurodegenerative disorders. However, significant obstacles remain and need to be overcome before translating the potential of neurotrophins into the therapeutic arena. This article addresses current efforts and advances in resolving these challenges and provides an overview of roadmaps for future translational research and neurotrophin-based drug developments. BioMed Central 2012-07-26 /pmc/articles/PMC3542569/ /pubmed/23210531 http://dx.doi.org/10.1186/2047-9158-1-14 Text en Copyright ©2012 Weissmiller and Wu; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Weissmiller, April M
Wu, Chengbiao
Current advances in using neurotrophic factors to treat neurodegenerative disorders
title Current advances in using neurotrophic factors to treat neurodegenerative disorders
title_full Current advances in using neurotrophic factors to treat neurodegenerative disorders
title_fullStr Current advances in using neurotrophic factors to treat neurodegenerative disorders
title_full_unstemmed Current advances in using neurotrophic factors to treat neurodegenerative disorders
title_short Current advances in using neurotrophic factors to treat neurodegenerative disorders
title_sort current advances in using neurotrophic factors to treat neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542569/
https://www.ncbi.nlm.nih.gov/pubmed/23210531
http://dx.doi.org/10.1186/2047-9158-1-14
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