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Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus
BACKGROUND: A high prevalence of autoimmune disease (AD) has been documented in relatives of adult patients with systemic lupus erythematosus (SLE). However, data on familial inheritance patterns in pediatric SLE patients is scarce. FINDINGS: The charts of 69 patients with pediatric-onset SLE were r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542590/ https://www.ncbi.nlm.nih.gov/pubmed/22891746 http://dx.doi.org/10.1186/1546-0096-10-22 |
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author | Walters, Heather M Pan, Nancy Moorthy, Lakshmi N Ward, Mary J Peterson, Margaret G Lehman, Thomas J |
author_facet | Walters, Heather M Pan, Nancy Moorthy, Lakshmi N Ward, Mary J Peterson, Margaret G Lehman, Thomas J |
author_sort | Walters, Heather M |
collection | PubMed |
description | BACKGROUND: A high prevalence of autoimmune disease (AD) has been documented in relatives of adult patients with systemic lupus erythematosus (SLE). However, data on familial inheritance patterns in pediatric SLE patients is scarce. FINDINGS: The charts of 69 patients with pediatric-onset SLE were reviewed retrospectively. The primary aim was to describe the prevalence and types of AD in relatives of children with SLE. The secondary aims were: 1) to compare severity of SLE in children with and without relatives affected by AD, and 2) to evaluate the impact of baseline demographics on severity of SLE in subjects. At diagnosis, 42% of subjects had one or more first, second, or third degree relative(s) with AD; and 32% of subjects had one or more first degree relative(s) with AD. The most common diseases in relatives of children with SLE were SLE (21%) and thyroid disease (15%). Subjects with no family history of AD were more likely to have severe SLE. SLE severity in subjects did not differ by gender. Children presenting with SLE at an earlier age were found to have more severe disease. CONCLUSIONS: This study demonstrated a high prevalence of AD in families of children with SLE, although a family history of AD did not correlate with more severe SLE in subjects. Future larger studies are necessary to elucidate patterns of familial inheritance and baseline patient characteristics that may affect severity of disease in pediatric SLE. |
format | Online Article Text |
id | pubmed-3542590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35425902013-01-11 Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus Walters, Heather M Pan, Nancy Moorthy, Lakshmi N Ward, Mary J Peterson, Margaret G Lehman, Thomas J Pediatr Rheumatol Online J Short Report BACKGROUND: A high prevalence of autoimmune disease (AD) has been documented in relatives of adult patients with systemic lupus erythematosus (SLE). However, data on familial inheritance patterns in pediatric SLE patients is scarce. FINDINGS: The charts of 69 patients with pediatric-onset SLE were reviewed retrospectively. The primary aim was to describe the prevalence and types of AD in relatives of children with SLE. The secondary aims were: 1) to compare severity of SLE in children with and without relatives affected by AD, and 2) to evaluate the impact of baseline demographics on severity of SLE in subjects. At diagnosis, 42% of subjects had one or more first, second, or third degree relative(s) with AD; and 32% of subjects had one or more first degree relative(s) with AD. The most common diseases in relatives of children with SLE were SLE (21%) and thyroid disease (15%). Subjects with no family history of AD were more likely to have severe SLE. SLE severity in subjects did not differ by gender. Children presenting with SLE at an earlier age were found to have more severe disease. CONCLUSIONS: This study demonstrated a high prevalence of AD in families of children with SLE, although a family history of AD did not correlate with more severe SLE in subjects. Future larger studies are necessary to elucidate patterns of familial inheritance and baseline patient characteristics that may affect severity of disease in pediatric SLE. BioMed Central 2012-08-14 /pmc/articles/PMC3542590/ /pubmed/22891746 http://dx.doi.org/10.1186/1546-0096-10-22 Text en Copyright ©2012 Walters et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Walters, Heather M Pan, Nancy Moorthy, Lakshmi N Ward, Mary J Peterson, Margaret G Lehman, Thomas J Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus |
title | Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus |
title_full | Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus |
title_fullStr | Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus |
title_full_unstemmed | Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus |
title_short | Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus |
title_sort | patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542590/ https://www.ncbi.nlm.nih.gov/pubmed/22891746 http://dx.doi.org/10.1186/1546-0096-10-22 |
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