Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca(2+) entry, mitochondrial perturbation and caspase overactivation

We have previously demonstrated that interrupting the protein–protein interaction (PPI) of β-tubulin:chaperonin-containing TCP-1β (CCT-β) induces the selective killing of multidrug-resistant cancer cells due to CCT-β overexpression. However, the molecular mechanism has not yet been identified. In th...

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Detalles Bibliográficos
Autores principales: Lin, Y-F, Lee, Y-F, Liang, P-H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542608/
https://www.ncbi.nlm.nih.gov/pubmed/23190606
http://dx.doi.org/10.1038/cddis.2012.173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542608/
https://www.ncbi.nlm.nih.gov/pubmed/23190606
http://dx.doi.org/10.1038/cddis.2012.173

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