Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor of RIPK1, Nec-1 inactive (Nec-1i), its inactive variant, and Nec-1 stable (Ne...

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Detalles Bibliográficos
Autores principales: Takahashi, N, Duprez, L, Grootjans, S, Cauwels, A, Nerinckx, W, DuHadaway, J B, Goossens, V, Roelandt, R, Van Hauwermeiren, F, Libert, C, Declercq, W, Callewaert, N, Prendergast, G C, Degterev, A, Yuan, J, Vandenabeele, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542611/
https://www.ncbi.nlm.nih.gov/pubmed/23190609
http://dx.doi.org/10.1038/cddis.2012.176

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