Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show variable potencies and a broad range of cytotoxic effects. Here, we report the structural analysis and antileukemic ac...

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Detalles Bibliográficos
Autores principales: Etchin, J, Sun, Q, Kentsis, A, Farmer, A, Zhang, Z C, Sanda, T, Mansour, M R, Barcelo, C, McCauley, D, Kauffman, M, Shacham, S, Christie, A L, Kung, A L, Rodig, S J, Chook, Y M, Look, A T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542631/
https://www.ncbi.nlm.nih.gov/pubmed/22847027
http://dx.doi.org/10.1038/leu.2012.219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542631/
https://www.ncbi.nlm.nih.gov/pubmed/22847027
http://dx.doi.org/10.1038/leu.2012.219

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