Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor

Amyloid-β (Aβ) is produced by the consecutive cleavage of amyloid precursor protein (APP) first by β-secretase, generating C99, and then by γ-secretase. APP is also cleaved by α-secretase. It is hypothesized that reducing the production of Aβ in the brain may slow the progression of Alzheimer diseas...

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Detalles Bibliográficos
Autores principales: Ortega, Fernando, Stott, Jonathan, Visser, Sandra A. G., Bendtsen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543028/
https://www.ncbi.nlm.nih.gov/pubmed/23152503
http://dx.doi.org/10.1074/jbc.M112.419135

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