Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis

Genetic factors explain a majority of risk variance for age-related macular degeneration (AMD). While genome-wide association studies (GWAS) for late AMD implicate genes in complement, inflammatory and lipid pathways, the genetic architecture of early AMD has been relatively under studied. We conduc...

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Detalles Bibliográficos
Autores principales: Holliday, Elizabeth G., Smith, Albert V., Cornes, Belinda K., Buitendijk, Gabriëlle H. S., Jensen, Richard A., Sim, Xueling, Aspelund, Thor, Aung, Tin, Baird, Paul N., Boerwinkle, Eric, Cheng, Ching Yu, van Duijn, Cornelia M., Eiriksdottir, Gudny, Gudnason, Vilmundur, Harris, Tamara, Hewitt, Alex W., Inouye, Michael, Jonasson, Fridbert, Klein, Barbara E. K., Launer, Lenore, Li, Xiaohui, Liew, Gerald, Lumley, Thomas, McElduff, Patrick, McKnight, Barbara, Mitchell, Paul, Psaty, Bruce M., Rochtchina, Elena, Rotter, Jerome I., Scott, Rodney J., Tay, Wanting, Taylor, Kent, Teo, Yik Ying, Uitterlinden, André G., Viswanathan, Ananth, Xie, Sophia, Vingerling, Johannes R., Klaver, Caroline C. W., Tai, E. Shyong, Siscovick, David, Klein, Ronald, Cotch, Mary Frances, Wong, Tien Y., Attia, John, Wang, Jie Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543264/
https://www.ncbi.nlm.nih.gov/pubmed/23326517
http://dx.doi.org/10.1371/journal.pone.0053830

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