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Effects of fish oil supplementation on inflammatory acne

BACKGROUND: Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity. METHODS: 13 individuals with inflammatory acne were gi...

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Detalles Bibliográficos
Autores principales: Khayef, Golandam, Young, Julia, Burns-Whitmore, Bonny, Spalding, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543297/
https://www.ncbi.nlm.nih.gov/pubmed/23206895
http://dx.doi.org/10.1186/1476-511X-11-165
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author Khayef, Golandam
Young, Julia
Burns-Whitmore, Bonny
Spalding, Thomas
author_facet Khayef, Golandam
Young, Julia
Burns-Whitmore, Bonny
Spalding, Thomas
author_sort Khayef, Golandam
collection PubMed
description BACKGROUND: Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity. METHODS: 13 individuals with inflammatory acne were given three grams of fish oil containing 930 mg of EPA to their unchanged diet and existing acne remedies for 12 weeks. Acne was assessed using an overall severity grading scale, total inflammatory lesion counts, and colorimetry. FINDINGS: There was no significant change in acne grading and inflammatory counts at week 12 compared to baseline. However, there was a broad range of response to the intervention on an individual basis. The results showed that acne severity improved in 8 individuals, worsened in 4, and remained unchanged in 1. Interestingly, among the individuals who showed improvement, 7 were classified as having moderate to severe acne at baseline, while 3 of the 4 whose acne deteriorated were classified as having mild acne. CONCLUSION: There is some evidence that fish oil supplementation is associated with an improvement in overall acne severity, especially for individuals with moderate to severe acne. Divergent responses to fish oil in our pilot study indicates that dietary and supplemental lipids are worthy of further investigation in acne.
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spelling pubmed-35432972013-01-14 Effects of fish oil supplementation on inflammatory acne Khayef, Golandam Young, Julia Burns-Whitmore, Bonny Spalding, Thomas Lipids Health Dis Short Report BACKGROUND: Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity. METHODS: 13 individuals with inflammatory acne were given three grams of fish oil containing 930 mg of EPA to their unchanged diet and existing acne remedies for 12 weeks. Acne was assessed using an overall severity grading scale, total inflammatory lesion counts, and colorimetry. FINDINGS: There was no significant change in acne grading and inflammatory counts at week 12 compared to baseline. However, there was a broad range of response to the intervention on an individual basis. The results showed that acne severity improved in 8 individuals, worsened in 4, and remained unchanged in 1. Interestingly, among the individuals who showed improvement, 7 were classified as having moderate to severe acne at baseline, while 3 of the 4 whose acne deteriorated were classified as having mild acne. CONCLUSION: There is some evidence that fish oil supplementation is associated with an improvement in overall acne severity, especially for individuals with moderate to severe acne. Divergent responses to fish oil in our pilot study indicates that dietary and supplemental lipids are worthy of further investigation in acne. BioMed Central 2012-12-03 /pmc/articles/PMC3543297/ /pubmed/23206895 http://dx.doi.org/10.1186/1476-511X-11-165 Text en Copyright ©2012 Khayef et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Khayef, Golandam
Young, Julia
Burns-Whitmore, Bonny
Spalding, Thomas
Effects of fish oil supplementation on inflammatory acne
title Effects of fish oil supplementation on inflammatory acne
title_full Effects of fish oil supplementation on inflammatory acne
title_fullStr Effects of fish oil supplementation on inflammatory acne
title_full_unstemmed Effects of fish oil supplementation on inflammatory acne
title_short Effects of fish oil supplementation on inflammatory acne
title_sort effects of fish oil supplementation on inflammatory acne
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543297/
https://www.ncbi.nlm.nih.gov/pubmed/23206895
http://dx.doi.org/10.1186/1476-511X-11-165
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