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Effects of fish oil supplementation on inflammatory acne
BACKGROUND: Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity. METHODS: 13 individuals with inflammatory acne were gi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543297/ https://www.ncbi.nlm.nih.gov/pubmed/23206895 http://dx.doi.org/10.1186/1476-511X-11-165 |
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author | Khayef, Golandam Young, Julia Burns-Whitmore, Bonny Spalding, Thomas |
author_facet | Khayef, Golandam Young, Julia Burns-Whitmore, Bonny Spalding, Thomas |
author_sort | Khayef, Golandam |
collection | PubMed |
description | BACKGROUND: Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity. METHODS: 13 individuals with inflammatory acne were given three grams of fish oil containing 930 mg of EPA to their unchanged diet and existing acne remedies for 12 weeks. Acne was assessed using an overall severity grading scale, total inflammatory lesion counts, and colorimetry. FINDINGS: There was no significant change in acne grading and inflammatory counts at week 12 compared to baseline. However, there was a broad range of response to the intervention on an individual basis. The results showed that acne severity improved in 8 individuals, worsened in 4, and remained unchanged in 1. Interestingly, among the individuals who showed improvement, 7 were classified as having moderate to severe acne at baseline, while 3 of the 4 whose acne deteriorated were classified as having mild acne. CONCLUSION: There is some evidence that fish oil supplementation is associated with an improvement in overall acne severity, especially for individuals with moderate to severe acne. Divergent responses to fish oil in our pilot study indicates that dietary and supplemental lipids are worthy of further investigation in acne. |
format | Online Article Text |
id | pubmed-3543297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35432972013-01-14 Effects of fish oil supplementation on inflammatory acne Khayef, Golandam Young, Julia Burns-Whitmore, Bonny Spalding, Thomas Lipids Health Dis Short Report BACKGROUND: Given that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity. METHODS: 13 individuals with inflammatory acne were given three grams of fish oil containing 930 mg of EPA to their unchanged diet and existing acne remedies for 12 weeks. Acne was assessed using an overall severity grading scale, total inflammatory lesion counts, and colorimetry. FINDINGS: There was no significant change in acne grading and inflammatory counts at week 12 compared to baseline. However, there was a broad range of response to the intervention on an individual basis. The results showed that acne severity improved in 8 individuals, worsened in 4, and remained unchanged in 1. Interestingly, among the individuals who showed improvement, 7 were classified as having moderate to severe acne at baseline, while 3 of the 4 whose acne deteriorated were classified as having mild acne. CONCLUSION: There is some evidence that fish oil supplementation is associated with an improvement in overall acne severity, especially for individuals with moderate to severe acne. Divergent responses to fish oil in our pilot study indicates that dietary and supplemental lipids are worthy of further investigation in acne. BioMed Central 2012-12-03 /pmc/articles/PMC3543297/ /pubmed/23206895 http://dx.doi.org/10.1186/1476-511X-11-165 Text en Copyright ©2012 Khayef et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Khayef, Golandam Young, Julia Burns-Whitmore, Bonny Spalding, Thomas Effects of fish oil supplementation on inflammatory acne |
title | Effects of fish oil supplementation on inflammatory acne |
title_full | Effects of fish oil supplementation on inflammatory acne |
title_fullStr | Effects of fish oil supplementation on inflammatory acne |
title_full_unstemmed | Effects of fish oil supplementation on inflammatory acne |
title_short | Effects of fish oil supplementation on inflammatory acne |
title_sort | effects of fish oil supplementation on inflammatory acne |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543297/ https://www.ncbi.nlm.nih.gov/pubmed/23206895 http://dx.doi.org/10.1186/1476-511X-11-165 |
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