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Nuclear hormone receptors in podocytes
Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543367/ https://www.ncbi.nlm.nih.gov/pubmed/22995171 http://dx.doi.org/10.1186/2045-3701-2-33 |
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author | Khurana, Simran Bruggeman, Leslie A Kao, Hung-Ying |
author_facet | Khurana, Simran Bruggeman, Leslie A Kao, Hung-Ying |
author_sort | Khurana, Simran |
collection | PubMed |
description | Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses. |
format | Online Article Text |
id | pubmed-3543367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35433672013-01-14 Nuclear hormone receptors in podocytes Khurana, Simran Bruggeman, Leslie A Kao, Hung-Ying Cell Biosci Review Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses. BioMed Central 2012-09-20 /pmc/articles/PMC3543367/ /pubmed/22995171 http://dx.doi.org/10.1186/2045-3701-2-33 Text en Copyright ©2012 Khurana et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Khurana, Simran Bruggeman, Leslie A Kao, Hung-Ying Nuclear hormone receptors in podocytes |
title | Nuclear hormone receptors in podocytes |
title_full | Nuclear hormone receptors in podocytes |
title_fullStr | Nuclear hormone receptors in podocytes |
title_full_unstemmed | Nuclear hormone receptors in podocytes |
title_short | Nuclear hormone receptors in podocytes |
title_sort | nuclear hormone receptors in podocytes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543367/ https://www.ncbi.nlm.nih.gov/pubmed/22995171 http://dx.doi.org/10.1186/2045-3701-2-33 |
work_keys_str_mv | AT khuranasimran nuclearhormonereceptorsinpodocytes AT bruggemanlesliea nuclearhormonereceptorsinpodocytes AT kaohungying nuclearhormonereceptorsinpodocytes |