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Nuclear hormone receptors in podocytes

Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in c...

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Detalles Bibliográficos
Autores principales: Khurana, Simran, Bruggeman, Leslie A, Kao, Hung-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543367/
https://www.ncbi.nlm.nih.gov/pubmed/22995171
http://dx.doi.org/10.1186/2045-3701-2-33
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author Khurana, Simran
Bruggeman, Leslie A
Kao, Hung-Ying
author_facet Khurana, Simran
Bruggeman, Leslie A
Kao, Hung-Ying
author_sort Khurana, Simran
collection PubMed
description Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses.
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spelling pubmed-35433672013-01-14 Nuclear hormone receptors in podocytes Khurana, Simran Bruggeman, Leslie A Kao, Hung-Ying Cell Biosci Review Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses. BioMed Central 2012-09-20 /pmc/articles/PMC3543367/ /pubmed/22995171 http://dx.doi.org/10.1186/2045-3701-2-33 Text en Copyright ©2012 Khurana et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Khurana, Simran
Bruggeman, Leslie A
Kao, Hung-Ying
Nuclear hormone receptors in podocytes
title Nuclear hormone receptors in podocytes
title_full Nuclear hormone receptors in podocytes
title_fullStr Nuclear hormone receptors in podocytes
title_full_unstemmed Nuclear hormone receptors in podocytes
title_short Nuclear hormone receptors in podocytes
title_sort nuclear hormone receptors in podocytes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543367/
https://www.ncbi.nlm.nih.gov/pubmed/22995171
http://dx.doi.org/10.1186/2045-3701-2-33
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