Cargando…
The incidence and clinical relevance of drug interactions in pediatrics
OBJECTIVE: To investigate the prevalence of the major drug interactions in children and verify the rate and profile of drug interactions in hospitalized pediatric patients. MATERIALS AND METHODS: A retrospective study was designed and data collected from the files of hospitalized children in Pulmono...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543549/ https://www.ncbi.nlm.nih.gov/pubmed/23326100 http://dx.doi.org/10.4103/0976-500X.103686 |
_version_ | 1782255676041461760 |
---|---|
author | Qorraj-Bytyqi, Hasime Hoxha, Rexhep Krasniqi, Shaip Bahtiri, Elton Kransiqi, Valon |
author_facet | Qorraj-Bytyqi, Hasime Hoxha, Rexhep Krasniqi, Shaip Bahtiri, Elton Kransiqi, Valon |
author_sort | Qorraj-Bytyqi, Hasime |
collection | PubMed |
description | OBJECTIVE: To investigate the prevalence of the major drug interactions in children and verify the rate and profile of drug interactions in hospitalized pediatric patients. MATERIALS AND METHODS: A retrospective study was designed and data collected from the files of hospitalized children in Pulmonology, Nephrology, and Gastroenterology wards of a Pediatric Clinic, from July 1999 to 2004. RESULTS: From the analyzed material, we detected 34 cases of interactions, of which 1 was pharmacodynamics interaction, 13 were pharmacokinetic interactions, and 20 of unknown mechanisms. According to the rate of significance, 4 cases were categorized in the first significance rate of interaction, 18 cases in the second significance rate, 1 case of the third significance rate, 4 cases of the fourth significance rate, and 7 cases of the fifth significance rate. According to onset of cases, 33 cases were of delayed onset, and according to severity of interactions, in 7 cases we noticed major severity interaction, in 19 cases moderate severity and in 8 cases minor severity. CONCLUSIONS: The presence of drug interactions is a permanent risk in the pediatric clinic. Then, we can conclude that continued education, computer system for prescriptions, pharmacotherapy monitoring of patients, and the pharmacist participation in the multidisciplinary team are some manners of improving the treatment to hospitalized patients. |
format | Online Article Text |
id | pubmed-3543549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35435492013-01-16 The incidence and clinical relevance of drug interactions in pediatrics Qorraj-Bytyqi, Hasime Hoxha, Rexhep Krasniqi, Shaip Bahtiri, Elton Kransiqi, Valon J Pharmacol Pharmacother Research Paper OBJECTIVE: To investigate the prevalence of the major drug interactions in children and verify the rate and profile of drug interactions in hospitalized pediatric patients. MATERIALS AND METHODS: A retrospective study was designed and data collected from the files of hospitalized children in Pulmonology, Nephrology, and Gastroenterology wards of a Pediatric Clinic, from July 1999 to 2004. RESULTS: From the analyzed material, we detected 34 cases of interactions, of which 1 was pharmacodynamics interaction, 13 were pharmacokinetic interactions, and 20 of unknown mechanisms. According to the rate of significance, 4 cases were categorized in the first significance rate of interaction, 18 cases in the second significance rate, 1 case of the third significance rate, 4 cases of the fourth significance rate, and 7 cases of the fifth significance rate. According to onset of cases, 33 cases were of delayed onset, and according to severity of interactions, in 7 cases we noticed major severity interaction, in 19 cases moderate severity and in 8 cases minor severity. CONCLUSIONS: The presence of drug interactions is a permanent risk in the pediatric clinic. Then, we can conclude that continued education, computer system for prescriptions, pharmacotherapy monitoring of patients, and the pharmacist participation in the multidisciplinary team are some manners of improving the treatment to hospitalized patients. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3543549/ /pubmed/23326100 http://dx.doi.org/10.4103/0976-500X.103686 Text en Copyright: © Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Qorraj-Bytyqi, Hasime Hoxha, Rexhep Krasniqi, Shaip Bahtiri, Elton Kransiqi, Valon The incidence and clinical relevance of drug interactions in pediatrics |
title | The incidence and clinical relevance of drug interactions in pediatrics |
title_full | The incidence and clinical relevance of drug interactions in pediatrics |
title_fullStr | The incidence and clinical relevance of drug interactions in pediatrics |
title_full_unstemmed | The incidence and clinical relevance of drug interactions in pediatrics |
title_short | The incidence and clinical relevance of drug interactions in pediatrics |
title_sort | incidence and clinical relevance of drug interactions in pediatrics |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543549/ https://www.ncbi.nlm.nih.gov/pubmed/23326100 http://dx.doi.org/10.4103/0976-500X.103686 |
work_keys_str_mv | AT qorrajbytyqihasime theincidenceandclinicalrelevanceofdruginteractionsinpediatrics AT hoxharexhep theincidenceandclinicalrelevanceofdruginteractionsinpediatrics AT krasniqishaip theincidenceandclinicalrelevanceofdruginteractionsinpediatrics AT bahtirielton theincidenceandclinicalrelevanceofdruginteractionsinpediatrics AT kransiqivalon theincidenceandclinicalrelevanceofdruginteractionsinpediatrics AT qorrajbytyqihasime incidenceandclinicalrelevanceofdruginteractionsinpediatrics AT hoxharexhep incidenceandclinicalrelevanceofdruginteractionsinpediatrics AT krasniqishaip incidenceandclinicalrelevanceofdruginteractionsinpediatrics AT bahtirielton incidenceandclinicalrelevanceofdruginteractionsinpediatrics AT kransiqivalon incidenceandclinicalrelevanceofdruginteractionsinpediatrics |