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The incidence and clinical relevance of drug interactions in pediatrics

OBJECTIVE: To investigate the prevalence of the major drug interactions in children and verify the rate and profile of drug interactions in hospitalized pediatric patients. MATERIALS AND METHODS: A retrospective study was designed and data collected from the files of hospitalized children in Pulmono...

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Autores principales: Qorraj-Bytyqi, Hasime, Hoxha, Rexhep, Krasniqi, Shaip, Bahtiri, Elton, Kransiqi, Valon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543549/
https://www.ncbi.nlm.nih.gov/pubmed/23326100
http://dx.doi.org/10.4103/0976-500X.103686
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author Qorraj-Bytyqi, Hasime
Hoxha, Rexhep
Krasniqi, Shaip
Bahtiri, Elton
Kransiqi, Valon
author_facet Qorraj-Bytyqi, Hasime
Hoxha, Rexhep
Krasniqi, Shaip
Bahtiri, Elton
Kransiqi, Valon
author_sort Qorraj-Bytyqi, Hasime
collection PubMed
description OBJECTIVE: To investigate the prevalence of the major drug interactions in children and verify the rate and profile of drug interactions in hospitalized pediatric patients. MATERIALS AND METHODS: A retrospective study was designed and data collected from the files of hospitalized children in Pulmonology, Nephrology, and Gastroenterology wards of a Pediatric Clinic, from July 1999 to 2004. RESULTS: From the analyzed material, we detected 34 cases of interactions, of which 1 was pharmacodynamics interaction, 13 were pharmacokinetic interactions, and 20 of unknown mechanisms. According to the rate of significance, 4 cases were categorized in the first significance rate of interaction, 18 cases in the second significance rate, 1 case of the third significance rate, 4 cases of the fourth significance rate, and 7 cases of the fifth significance rate. According to onset of cases, 33 cases were of delayed onset, and according to severity of interactions, in 7 cases we noticed major severity interaction, in 19 cases moderate severity and in 8 cases minor severity. CONCLUSIONS: The presence of drug interactions is a permanent risk in the pediatric clinic. Then, we can conclude that continued education, computer system for prescriptions, pharmacotherapy monitoring of patients, and the pharmacist participation in the multidisciplinary team are some manners of improving the treatment to hospitalized patients.
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spelling pubmed-35435492013-01-16 The incidence and clinical relevance of drug interactions in pediatrics Qorraj-Bytyqi, Hasime Hoxha, Rexhep Krasniqi, Shaip Bahtiri, Elton Kransiqi, Valon J Pharmacol Pharmacother Research Paper OBJECTIVE: To investigate the prevalence of the major drug interactions in children and verify the rate and profile of drug interactions in hospitalized pediatric patients. MATERIALS AND METHODS: A retrospective study was designed and data collected from the files of hospitalized children in Pulmonology, Nephrology, and Gastroenterology wards of a Pediatric Clinic, from July 1999 to 2004. RESULTS: From the analyzed material, we detected 34 cases of interactions, of which 1 was pharmacodynamics interaction, 13 were pharmacokinetic interactions, and 20 of unknown mechanisms. According to the rate of significance, 4 cases were categorized in the first significance rate of interaction, 18 cases in the second significance rate, 1 case of the third significance rate, 4 cases of the fourth significance rate, and 7 cases of the fifth significance rate. According to onset of cases, 33 cases were of delayed onset, and according to severity of interactions, in 7 cases we noticed major severity interaction, in 19 cases moderate severity and in 8 cases minor severity. CONCLUSIONS: The presence of drug interactions is a permanent risk in the pediatric clinic. Then, we can conclude that continued education, computer system for prescriptions, pharmacotherapy monitoring of patients, and the pharmacist participation in the multidisciplinary team are some manners of improving the treatment to hospitalized patients. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3543549/ /pubmed/23326100 http://dx.doi.org/10.4103/0976-500X.103686 Text en Copyright: © Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Qorraj-Bytyqi, Hasime
Hoxha, Rexhep
Krasniqi, Shaip
Bahtiri, Elton
Kransiqi, Valon
The incidence and clinical relevance of drug interactions in pediatrics
title The incidence and clinical relevance of drug interactions in pediatrics
title_full The incidence and clinical relevance of drug interactions in pediatrics
title_fullStr The incidence and clinical relevance of drug interactions in pediatrics
title_full_unstemmed The incidence and clinical relevance of drug interactions in pediatrics
title_short The incidence and clinical relevance of drug interactions in pediatrics
title_sort incidence and clinical relevance of drug interactions in pediatrics
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543549/
https://www.ncbi.nlm.nih.gov/pubmed/23326100
http://dx.doi.org/10.4103/0976-500X.103686
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