Cargando…

Toxic epidermal necrolysis due to lamotrigine in a pediatric patient

A 12-year-male child developed toxic epidermal necrolysis (TEN) probably due to lamotrigine. The patient was on antiepileptic therapy (sodium valproate and clonazepam) since 6–7 months, and lamotrigine was added in the regimen 1–2 months back. A serious cutaneous reaction is more likely to occur dur...

Descripción completa

Detalles Bibliográficos
Autores principales: Barvaliya, Manish J., Patel, Mahendra K., Patel, Tejas K., Tripathi, C. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543558/
https://www.ncbi.nlm.nih.gov/pubmed/23326109
http://dx.doi.org/10.4103/0976-500X.103695
_version_ 1782255678154342400
author Barvaliya, Manish J.
Patel, Mahendra K.
Patel, Tejas K.
Tripathi, C. B.
author_facet Barvaliya, Manish J.
Patel, Mahendra K.
Patel, Tejas K.
Tripathi, C. B.
author_sort Barvaliya, Manish J.
collection PubMed
description A 12-year-male child developed toxic epidermal necrolysis (TEN) probably due to lamotrigine. The patient was on antiepileptic therapy (sodium valproate and clonazepam) since 6–7 months, and lamotrigine was added in the regimen 1–2 months back. A serious cutaneous reaction is more likely to occur during the first 2 months of starting lamotrigine. The use of lamotrigine as an add-on to valproate may have precipitated the reaction. Other drugs were ruled out based on the incubation period of TEN. Drug interactions should be kept in mind with multiple antiepileptic therapies. The patient died because of the severity of reactions and delay in starting the treatment with steroids. One must be vigilant in early detection of the reaction.
format Online
Article
Text
id pubmed-3543558
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-35435582013-01-16 Toxic epidermal necrolysis due to lamotrigine in a pediatric patient Barvaliya, Manish J. Patel, Mahendra K. Patel, Tejas K. Tripathi, C. B. J Pharmacol Pharmacother Case Report A 12-year-male child developed toxic epidermal necrolysis (TEN) probably due to lamotrigine. The patient was on antiepileptic therapy (sodium valproate and clonazepam) since 6–7 months, and lamotrigine was added in the regimen 1–2 months back. A serious cutaneous reaction is more likely to occur during the first 2 months of starting lamotrigine. The use of lamotrigine as an add-on to valproate may have precipitated the reaction. Other drugs were ruled out based on the incubation period of TEN. Drug interactions should be kept in mind with multiple antiepileptic therapies. The patient died because of the severity of reactions and delay in starting the treatment with steroids. One must be vigilant in early detection of the reaction. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3543558/ /pubmed/23326109 http://dx.doi.org/10.4103/0976-500X.103695 Text en Copyright: © Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Barvaliya, Manish J.
Patel, Mahendra K.
Patel, Tejas K.
Tripathi, C. B.
Toxic epidermal necrolysis due to lamotrigine in a pediatric patient
title Toxic epidermal necrolysis due to lamotrigine in a pediatric patient
title_full Toxic epidermal necrolysis due to lamotrigine in a pediatric patient
title_fullStr Toxic epidermal necrolysis due to lamotrigine in a pediatric patient
title_full_unstemmed Toxic epidermal necrolysis due to lamotrigine in a pediatric patient
title_short Toxic epidermal necrolysis due to lamotrigine in a pediatric patient
title_sort toxic epidermal necrolysis due to lamotrigine in a pediatric patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543558/
https://www.ncbi.nlm.nih.gov/pubmed/23326109
http://dx.doi.org/10.4103/0976-500X.103695
work_keys_str_mv AT barvaliyamanishj toxicepidermalnecrolysisduetolamotrigineinapediatricpatient
AT patelmahendrak toxicepidermalnecrolysisduetolamotrigineinapediatricpatient
AT pateltejask toxicepidermalnecrolysisduetolamotrigineinapediatricpatient
AT tripathicb toxicepidermalnecrolysisduetolamotrigineinapediatricpatient