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High serum glucose levels are associated with a higher perceived age

Estimating perceived age by facial photographs is a good estimate of health in elderly populations. Previously, we showed that familial longevity is marked by a more beneficial glucose metabolism already at middle age. As glucose is also related to skin aging, this study aimed to investigate the ass...

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Autores principales: Noordam, Raymond, Gunn, David A., Tomlin, Cyrena C., Maier, Andrea B., Mooijaart, Simon P., Slagboom, P. Eline, Westendorp, Rudi G. J., de Craen, Anton J. M., van Heemst, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543736/
https://www.ncbi.nlm.nih.gov/pubmed/22102339
http://dx.doi.org/10.1007/s11357-011-9339-9
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author Noordam, Raymond
Gunn, David A.
Tomlin, Cyrena C.
Maier, Andrea B.
Mooijaart, Simon P.
Slagboom, P. Eline
Westendorp, Rudi G. J.
de Craen, Anton J. M.
van Heemst, Diana
author_facet Noordam, Raymond
Gunn, David A.
Tomlin, Cyrena C.
Maier, Andrea B.
Mooijaart, Simon P.
Slagboom, P. Eline
Westendorp, Rudi G. J.
de Craen, Anton J. M.
van Heemst, Diana
author_sort Noordam, Raymond
collection PubMed
description Estimating perceived age by facial photographs is a good estimate of health in elderly populations. Previously, we showed that familial longevity is marked by a more beneficial glucose metabolism already at middle age. As glucose is also related to skin aging, this study aimed to investigate the association between glucose metabolism and perceived age. Perceived age was assessed using facial photographs and non-fasted glucose and insulin were measured in 602 subjects from the Leiden Longevity Study. Non-diabetic subjects (n = 569) were divided in three strata according to their glucose levels, and diabetic subjects (n = 33; as a proxy of long-term hyperglycemic exposure) were included as a fourth stratum. Considered confounding factors were gender, chronological age, current smoking, body mass index, photo-damage score, and insulin levels. Perceived age was increased from 59.6 years (SE = 0.3) in the first stratum to 61.2 years (SE = 0.6) in diabetic subjects (p for trend = 0.002). In non-diabetic subjects only, perceived age was increased from 59.6 years (SE = 0.3) in the first stratum to 60.6 years (SE = 0.3) in the third stratum (p for trend = 0.009). Continuously, perceived age increased 0.40 years (SE = 0.14, p = 0.006) per 1 mmol/L increase in glucose level in non-diabetic subjects. The present study demonstrates that, also among non-diabetic subjects, higher glucose levels are associated with a higher perceived age. Future research should be focused on elucidating possible mechanisms linking glucose levels to perceived age. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11357-011-9339-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-35437362013-01-14 High serum glucose levels are associated with a higher perceived age Noordam, Raymond Gunn, David A. Tomlin, Cyrena C. Maier, Andrea B. Mooijaart, Simon P. Slagboom, P. Eline Westendorp, Rudi G. J. de Craen, Anton J. M. van Heemst, Diana Age (Dordr) Article Estimating perceived age by facial photographs is a good estimate of health in elderly populations. Previously, we showed that familial longevity is marked by a more beneficial glucose metabolism already at middle age. As glucose is also related to skin aging, this study aimed to investigate the association between glucose metabolism and perceived age. Perceived age was assessed using facial photographs and non-fasted glucose and insulin were measured in 602 subjects from the Leiden Longevity Study. Non-diabetic subjects (n = 569) were divided in three strata according to their glucose levels, and diabetic subjects (n = 33; as a proxy of long-term hyperglycemic exposure) were included as a fourth stratum. Considered confounding factors were gender, chronological age, current smoking, body mass index, photo-damage score, and insulin levels. Perceived age was increased from 59.6 years (SE = 0.3) in the first stratum to 61.2 years (SE = 0.6) in diabetic subjects (p for trend = 0.002). In non-diabetic subjects only, perceived age was increased from 59.6 years (SE = 0.3) in the first stratum to 60.6 years (SE = 0.3) in the third stratum (p for trend = 0.009). Continuously, perceived age increased 0.40 years (SE = 0.14, p = 0.006) per 1 mmol/L increase in glucose level in non-diabetic subjects. The present study demonstrates that, also among non-diabetic subjects, higher glucose levels are associated with a higher perceived age. Future research should be focused on elucidating possible mechanisms linking glucose levels to perceived age. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11357-011-9339-9) contains supplementary material, which is available to authorized users. Springer Netherlands 2011-11-20 2013-02 /pmc/articles/PMC3543736/ /pubmed/22102339 http://dx.doi.org/10.1007/s11357-011-9339-9 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Noordam, Raymond
Gunn, David A.
Tomlin, Cyrena C.
Maier, Andrea B.
Mooijaart, Simon P.
Slagboom, P. Eline
Westendorp, Rudi G. J.
de Craen, Anton J. M.
van Heemst, Diana
High serum glucose levels are associated with a higher perceived age
title High serum glucose levels are associated with a higher perceived age
title_full High serum glucose levels are associated with a higher perceived age
title_fullStr High serum glucose levels are associated with a higher perceived age
title_full_unstemmed High serum glucose levels are associated with a higher perceived age
title_short High serum glucose levels are associated with a higher perceived age
title_sort high serum glucose levels are associated with a higher perceived age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543736/
https://www.ncbi.nlm.nih.gov/pubmed/22102339
http://dx.doi.org/10.1007/s11357-011-9339-9
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