Cargando…

Adipose Tissue-Specific Deletion of 12/15-Lipoxygenase Protects Mice from the Consequences of a High-Fat Diet

Type 2 diabetes is associated with obesity, insulin resistance, and inflammation in adipose tissue. 12/15-Lipoxygenase (12/15-LO) generates proinflammatory lipid mediators, which induce inflammation in adipose tissue. Therefore we investigated the role of 12/15-LO activity in mouse white adipose tis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cole, Banumathi K., Morris, Margaret A., Grzesik, Wojciech J., Leone, Kendall A., Nadler, Jerry L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543811/ https://www.ncbi.nlm.nih.gov/pubmed/23326022 http://dx.doi.org/10.1155/2012/851798

Ejemplares similares

Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15(null) Mice, Leading to Protection against Type 1 Diabetes Development
por: Green-Mitchell, Shamina M., et al.
Publicado: (2013)

12/15-Lipoxygenase Is Required for the Early Onset of High Fat Diet-Induced Adipose Tissue Inflammation and Insulin Resistance in Mice
por: Sears, Dorothy D., et al.
Publicado: (2009)

Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury
por: Rossaint, Jan, et al.
Publicado: (2012)

Regulation of Tissue Inflammation by 12-Lipoxygenases
por: Kulkarni, Abhishek, et al.
Publicado: (2021)

12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes
por: Kulkarni, Abhishek, et al.
Publicado: (2021)

The contribution of arachidonate 15-lipoxygenase in tissue macrophages to adipose tissue remodeling
por: Kwon, H-J, et al.
Publicado: (2016)

Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes
por: Hernandez-Perez, Marimar, et al.
Publicado: (2017)

Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease
por: Middleton, Melissa Kristine, et al.
Publicado: (2006)

A novel role for 12/15-lipoxygenase in regulating autophagy
por: Morgan, Alwena H., et al.
Publicado: (2014)

12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes
por: Cakir-Aktas, Canan, et al.
Publicado: (2023)

Myeloid-specific deletion of NOX2 prevents the metabolic and neurologic consequences of high fat diet
por: Pepping, Jennifer K., et al.
Publicado: (2017)

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
por: Gheorghe, Karina Roxana, et al.
Publicado: (2009)

Reduced Dietary Omega-6 to Omega-3 Fatty Acid Ratio and 12/15-Lipoxygenase Deficiency Are Protective against Chronic High Fat Diet-Induced Steatohepatitis
por: Lazic, Milos, et al.
Publicado: (2014)

12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation
por: Lindley, Alexa R., et al.
Publicado: (2010)

Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure
por: Kayama, Yosuke, et al.
Publicado: (2009)

Involvement of 15-lipoxygenase in early stages of atherogenesis
Publicado: (1994)

Regulation and Functions of 15-Lipoxygenases in Human Macrophages
por: Snodgrass, Ryan G., et al.
Publicado: (2019)

12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance
por: Uderhardt, Stefan, et al.
Publicado: (2011)

The role of 15 lipoxygenase 1 in asthma comes into focus
por: Boyce, Joshua A.
Publicado: (2022)

Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies
por: Rai, Ganesha, et al.
Publicado: (2014)

Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes
por: Jin, Jing, et al.
Publicado: (2021)

12/15-Lipoxygenase Regulates IL-33-Induced Eosinophilic Airway Inflammation in Mice
por: Miyata, Jun, et al.
Publicado: (2021)

Effects of Inflammatory Factor Expression Regulated by 12/15 Lipoxygenase on Obesity-Related Nephropathy
por: Liu, Nian, et al.
Publicado: (2022)

Hematopoietic 12/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma
por: Makullah, Mgayya, et al.
Publicado: (2023)

Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes
por: Nyalwidhe, Julius O., et al.
Publicado: (2017)

Tumor-suppressing 15-Lipoxygenase-2: Time for prime time?
por: Guo, Yande, et al.
Publicado: (2014)

15-Lipoxygenase-1 Is Involved in the Effects of Atorvastatin on Endothelial Dysfunction
por: Zhang, Peng, et al.
Publicado: (2016)

The green microalga Lobosphaera incisa harbours an arachidonate 15S‐lipoxygenase
por: Djian, B., et al.
Publicado: (2018)

12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma
por: Mabalirajan, Ulaganathan, et al.
Publicado: (2013)

12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus
por: Mackel, Joseph J., et al.
Publicado: (2020)

12/15-Lipoxygenase Regulation of Diabetic Cognitive Dysfunction Is Determined by Interfering with Inflammation and Cell Apoptosis
por: Chen, Qi, et al.
Publicado: (2022)

Inhibition of 5-lipoxygenase inhibitor zileuton in high-fat diet-induced nonalcoholic fatty liver disease progression model
por: Ma, Kuifen, et al.
Publicado: (2017)

Increased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis
por: Chen, Kaizhe, et al.
Publicado: (2017)

Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors
por: Sadeghian, Hamid, et al.
Publicado: (2018)

Structural Dynamics of 15-Lipoxygenase-2 via Hydrogen–Deuterium Exchange
por: Droege, Kristin D., et al.
Publicado: (2017)

A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus
por: He, Kaiying, et al.
Publicado: (2023)

Host Factors Alter Effects of Angiopoietin-Like Protein 8 on Glucose Homeostasis in Diabetic Mice
por: Liu, Sichen, et al.
Publicado: (2016)

Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo
por: Zieger, Konstanze, et al.
Publicado: (2017)

12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis
por: Jackson, Christa D., et al.
Publicado: (2023)

Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation
por: Popmihajlov, Zoran, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_3hkqqpn9d3vs46djnj40q25nrr