Fatal poisoning by isoniazid and rifampicin

Isoniazid and rifampicin are used for management of tuberculosis. Acute poisoning due to isoniazid overdose is associated with repetitive generalized tonic-clonic seizures and severe metabolic acidosis. In toxic doses, rifampicin is known to produce hepatic, renal, hematological disorders, and convu...

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Autores principales: Sridhar, A., Sandeep, Y., Krishnakishore, C., Sriramnaveen, P., Manjusha, Y., Sivakumar, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544064/
https://www.ncbi.nlm.nih.gov/pubmed/23326053
http://dx.doi.org/10.4103/0971-4065.103930
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author Sridhar, A.
Sandeep, Y.
Krishnakishore, C.
Sriramnaveen, P.
Manjusha, Y.
Sivakumar, V.
author_facet Sridhar, A.
Sandeep, Y.
Krishnakishore, C.
Sriramnaveen, P.
Manjusha, Y.
Sivakumar, V.
author_sort Sridhar, A.
collection PubMed
description Isoniazid and rifampicin are used for management of tuberculosis. Acute poisoning due to isoniazid overdose is associated with repetitive generalized tonic-clonic seizures and severe metabolic acidosis. In toxic doses, rifampicin is known to produce hepatic, renal, hematological disorders, and convulsions. Sometimes, it may produce red man syndrome. We report a case of fatal poisoning with isoniazid and rifampicin. The case was characterized by late presentation, lactic acidosis, and renal failure.
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spelling pubmed-35440642013-01-16 Fatal poisoning by isoniazid and rifampicin Sridhar, A. Sandeep, Y. Krishnakishore, C. Sriramnaveen, P. Manjusha, Y. Sivakumar, V. Indian J Nephrol Case Report Isoniazid and rifampicin are used for management of tuberculosis. Acute poisoning due to isoniazid overdose is associated with repetitive generalized tonic-clonic seizures and severe metabolic acidosis. In toxic doses, rifampicin is known to produce hepatic, renal, hematological disorders, and convulsions. Sometimes, it may produce red man syndrome. We report a case of fatal poisoning with isoniazid and rifampicin. The case was characterized by late presentation, lactic acidosis, and renal failure. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3544064/ /pubmed/23326053 http://dx.doi.org/10.4103/0971-4065.103930 Text en Copyright: © Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sridhar, A.
Sandeep, Y.
Krishnakishore, C.
Sriramnaveen, P.
Manjusha, Y.
Sivakumar, V.
Fatal poisoning by isoniazid and rifampicin
title Fatal poisoning by isoniazid and rifampicin
title_full Fatal poisoning by isoniazid and rifampicin
title_fullStr Fatal poisoning by isoniazid and rifampicin
title_full_unstemmed Fatal poisoning by isoniazid and rifampicin
title_short Fatal poisoning by isoniazid and rifampicin
title_sort fatal poisoning by isoniazid and rifampicin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544064/
https://www.ncbi.nlm.nih.gov/pubmed/23326053
http://dx.doi.org/10.4103/0971-4065.103930
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