The effect of red grape juice on Alzheimer's disease in rats

BACKGROUND: Alzheimer's disease is a neurodegenerative disease appearing as a result of free radicals and oxidative stress. Antioxidants agents boost memory and control Alzheimer's disease. Since red grape juice contains antioxidant agents, its effects on speed of learning and improvement...

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Autores principales: Siahmard, Zahra, Alaei, Hojjatollah, Reisi, Parham, Pilehvarian, Ali Asghar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544087/
https://www.ncbi.nlm.nih.gov/pubmed/23326794
http://dx.doi.org/10.4103/2277-9175.100188
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author Siahmard, Zahra
Alaei, Hojjatollah
Reisi, Parham
Pilehvarian, Ali Asghar
author_facet Siahmard, Zahra
Alaei, Hojjatollah
Reisi, Parham
Pilehvarian, Ali Asghar
author_sort Siahmard, Zahra
collection PubMed
description BACKGROUND: Alzheimer's disease is a neurodegenerative disease appearing as a result of free radicals and oxidative stress. Antioxidants agents boost memory and control Alzheimer's disease. Since red grape juice contains antioxidant agents, its effects on speed of learning and improvement of memory was studied in Alzheimer's rats. MATERIALS AND METHODS: Alzheimer's model was induced by bilateral infusion of streptozocine into lateral ventricles of brain of male rats. Rats drank 10% red grape juice for 21 days. Passive avoidance learning test was used for measuring memory and learning in rats. RESULTS: Our results showed that learning and memory in STZ-group decreased significantly compared to Sham group. However, intake of red grape juice increased speed of learning and improvement of memory in Alzheimer's rats. CONCLUSIONS: Our results suggest that there are active ingredients in red grape juice, which probably have therapeutic and preventive effects on cognitive impairments in Alzheimer's disease.
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spelling pubmed-35440872013-01-16 The effect of red grape juice on Alzheimer's disease in rats Siahmard, Zahra Alaei, Hojjatollah Reisi, Parham Pilehvarian, Ali Asghar Adv Biomed Res Original Article BACKGROUND: Alzheimer's disease is a neurodegenerative disease appearing as a result of free radicals and oxidative stress. Antioxidants agents boost memory and control Alzheimer's disease. Since red grape juice contains antioxidant agents, its effects on speed of learning and improvement of memory was studied in Alzheimer's rats. MATERIALS AND METHODS: Alzheimer's model was induced by bilateral infusion of streptozocine into lateral ventricles of brain of male rats. Rats drank 10% red grape juice for 21 days. Passive avoidance learning test was used for measuring memory and learning in rats. RESULTS: Our results showed that learning and memory in STZ-group decreased significantly compared to Sham group. However, intake of red grape juice increased speed of learning and improvement of memory in Alzheimer's rats. CONCLUSIONS: Our results suggest that there are active ingredients in red grape juice, which probably have therapeutic and preventive effects on cognitive impairments in Alzheimer's disease. Medknow Publications & Media Pvt Ltd 2012-08-28 /pmc/articles/PMC3544087/ /pubmed/23326794 http://dx.doi.org/10.4103/2277-9175.100188 Text en Copyright: © 2012 Siahmard http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Siahmard, Zahra
Alaei, Hojjatollah
Reisi, Parham
Pilehvarian, Ali Asghar
The effect of red grape juice on Alzheimer's disease in rats
title The effect of red grape juice on Alzheimer's disease in rats
title_full The effect of red grape juice on Alzheimer's disease in rats
title_fullStr The effect of red grape juice on Alzheimer's disease in rats
title_full_unstemmed The effect of red grape juice on Alzheimer's disease in rats
title_short The effect of red grape juice on Alzheimer's disease in rats
title_sort effect of red grape juice on alzheimer's disease in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544087/
https://www.ncbi.nlm.nih.gov/pubmed/23326794
http://dx.doi.org/10.4103/2277-9175.100188
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