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Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments

BACKGROUND: Neurocognitive deficits and decrease in intelligence quotient (IQ) is one of the complication of prophylactic central nervous system (CNS) treatment in acute lymphoblastic leukemia (ALL) patients. In this study, we compare the IQ in survivors of ALL that were treated with different proph...

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Autores principales: Nahid, Reisi, Leila, Khalilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544107/
https://www.ncbi.nlm.nih.gov/pubmed/23326813
http://dx.doi.org/10.4103/2277-9175.103005
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author Nahid, Reisi
Leila, Khalilian
author_facet Nahid, Reisi
Leila, Khalilian
author_sort Nahid, Reisi
collection PubMed
description BACKGROUND: Neurocognitive deficits and decrease in intelligence quotient (IQ) is one of the complication of prophylactic central nervous system (CNS) treatment in acute lymphoblastic leukemia (ALL) patients. In this study, we compare the IQ in survivors of ALL that were treated with different prophylactic CNS treatments. MATERIALS AND METHODS: We compared 43 long-term survivors of ALL: 21 survivors with intrathecal methotrexate (IT MTX) as CNS prophylaxis, 22 with IT MTX+1800-2400 rads cranial irradiation and 20 healthy controls. The IQ was measured using the Raven's test in these patients. RESULTS: Raven's test revealed significant differences in IQ between the survivors of ALL that were treated with IT MTX, IT MTX plus cranial irradiation and control group. There was no significant difference in the IQ with respect to sex, age and irradiation dose. CONCLUSION: We can that reveal that CNS prophylaxis treatment, especially the combined treatment, is associated with IQ score decline in ALL survivors. Therefore,a baseline and an annual assessment of their educational progress are suggested.
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spelling pubmed-35441072013-01-16 Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments Nahid, Reisi Leila, Khalilian Adv Biomed Res Original Article BACKGROUND: Neurocognitive deficits and decrease in intelligence quotient (IQ) is one of the complication of prophylactic central nervous system (CNS) treatment in acute lymphoblastic leukemia (ALL) patients. In this study, we compare the IQ in survivors of ALL that were treated with different prophylactic CNS treatments. MATERIALS AND METHODS: We compared 43 long-term survivors of ALL: 21 survivors with intrathecal methotrexate (IT MTX) as CNS prophylaxis, 22 with IT MTX+1800-2400 rads cranial irradiation and 20 healthy controls. The IQ was measured using the Raven's test in these patients. RESULTS: Raven's test revealed significant differences in IQ between the survivors of ALL that were treated with IT MTX, IT MTX plus cranial irradiation and control group. There was no significant difference in the IQ with respect to sex, age and irradiation dose. CONCLUSION: We can that reveal that CNS prophylaxis treatment, especially the combined treatment, is associated with IQ score decline in ALL survivors. Therefore,a baseline and an annual assessment of their educational progress are suggested. Medknow Publications & Media Pvt Ltd 2012-10-31 /pmc/articles/PMC3544107/ /pubmed/23326813 http://dx.doi.org/10.4103/2277-9175.103005 Text en Copyright: © 2012 Nahid http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Nahid, Reisi
Leila, Khalilian
Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments
title Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments
title_full Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments
title_fullStr Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments
title_full_unstemmed Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments
title_short Comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments
title_sort comparison of intelligence quotient in children surviving leukemia who received different prophylactic central nervous system treatments
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544107/
https://www.ncbi.nlm.nih.gov/pubmed/23326813
http://dx.doi.org/10.4103/2277-9175.103005
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