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Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease

BACKGROUND: Alzheimer's disease (AD) is a prevalent disorder with severe learning and memory defects. Because it has been demonstrated that erythropoietin (EPO) has positive effects on the central nervous system, the aim of this study was to evaluate the effect of EPO on neuronal proliferation...

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Autores principales: Arabpoor, Zohreh, Hamidi, Gholamali, Rashidi, Bahman, Shabrang, Moloud, Alaei, Hojjatallah, Sharifi, Mohammad Reza, Salami, Mahmoud, Dolatabadi, Hamid Reza Dehghani, Reisi, Parham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544128/
https://www.ncbi.nlm.nih.gov/pubmed/23326781
http://dx.doi.org/10.4103/2277-9175.100157
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author Arabpoor, Zohreh
Hamidi, Gholamali
Rashidi, Bahman
Shabrang, Moloud
Alaei, Hojjatallah
Sharifi, Mohammad Reza
Salami, Mahmoud
Dolatabadi, Hamid Reza Dehghani
Reisi, Parham
author_facet Arabpoor, Zohreh
Hamidi, Gholamali
Rashidi, Bahman
Shabrang, Moloud
Alaei, Hojjatallah
Sharifi, Mohammad Reza
Salami, Mahmoud
Dolatabadi, Hamid Reza Dehghani
Reisi, Parham
author_sort Arabpoor, Zohreh
collection PubMed
description BACKGROUND: Alzheimer's disease (AD) is a prevalent disorder with severe learning and memory defects. Because it has been demonstrated that erythropoietin (EPO) has positive effects on the central nervous system, the aim of this study was to evaluate the effect of EPO on neuronal proliferation in dentate gyrus of hippocampal formation in a well-defined model for AD. MATERIALS AND METHODS: A rat model of sporadic dementia of Alzheimer's type was established by a bilateral intracerebroventricular injection of streptozotocin (ICV-STZ). Impairment of learning and memory was confirmed 2 weeks after ICV-STZ injection by passive avoidance learning test and then rats were divided into fourgroups:Control, control-EPO, Alzheimer and Alzheimer-EPO. EPO was injected intraperitoneally every other day with a dose of 5000 IU/kg and, finally, the rats were anesthetized and decapitated for immunohistochemical study and neurogenesis investigation (by Ki67 method) in dentate gyrus of hippocampal formation. RESULTS: The results driven from the histological study showed that EPO significantly increases neuronal proliferation in dentate gyrus of hippocampus in the Alzheimer-EPO group compared with the control, control-EPO and Alzheimer groups; however, there were no differences between the other groups. CONCLUSION: Our results show that even though EPO in intact animals doesnot change neurogenesis in dentate gyrus, it can nonetheless significantly increase neurogenesis if there is an underlying disorder like neurodegenerative diseases.
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spelling pubmed-35441282013-01-16 Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease Arabpoor, Zohreh Hamidi, Gholamali Rashidi, Bahman Shabrang, Moloud Alaei, Hojjatallah Sharifi, Mohammad Reza Salami, Mahmoud Dolatabadi, Hamid Reza Dehghani Reisi, Parham Adv Biomed Res Original Article BACKGROUND: Alzheimer's disease (AD) is a prevalent disorder with severe learning and memory defects. Because it has been demonstrated that erythropoietin (EPO) has positive effects on the central nervous system, the aim of this study was to evaluate the effect of EPO on neuronal proliferation in dentate gyrus of hippocampal formation in a well-defined model for AD. MATERIALS AND METHODS: A rat model of sporadic dementia of Alzheimer's type was established by a bilateral intracerebroventricular injection of streptozotocin (ICV-STZ). Impairment of learning and memory was confirmed 2 weeks after ICV-STZ injection by passive avoidance learning test and then rats were divided into fourgroups:Control, control-EPO, Alzheimer and Alzheimer-EPO. EPO was injected intraperitoneally every other day with a dose of 5000 IU/kg and, finally, the rats were anesthetized and decapitated for immunohistochemical study and neurogenesis investigation (by Ki67 method) in dentate gyrus of hippocampal formation. RESULTS: The results driven from the histological study showed that EPO significantly increases neuronal proliferation in dentate gyrus of hippocampus in the Alzheimer-EPO group compared with the control, control-EPO and Alzheimer groups; however, there were no differences between the other groups. CONCLUSION: Our results show that even though EPO in intact animals doesnot change neurogenesis in dentate gyrus, it can nonetheless significantly increase neurogenesis if there is an underlying disorder like neurodegenerative diseases. Medknow Publications & Media Pvt Ltd 2012-08-28 /pmc/articles/PMC3544128/ /pubmed/23326781 http://dx.doi.org/10.4103/2277-9175.100157 Text en Copyright: © 2012 Arabpoor http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Arabpoor, Zohreh
Hamidi, Gholamali
Rashidi, Bahman
Shabrang, Moloud
Alaei, Hojjatallah
Sharifi, Mohammad Reza
Salami, Mahmoud
Dolatabadi, Hamid Reza Dehghani
Reisi, Parham
Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease
title Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease
title_full Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease
title_fullStr Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease
title_full_unstemmed Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease
title_short Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease
title_sort erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of alzheimer's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544128/
https://www.ncbi.nlm.nih.gov/pubmed/23326781
http://dx.doi.org/10.4103/2277-9175.100157
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