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Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease
BACKGROUND: Alzheimer's disease (AD) is a prevalent disorder with severe learning and memory defects. Because it has been demonstrated that erythropoietin (EPO) has positive effects on the central nervous system, the aim of this study was to evaluate the effect of EPO on neuronal proliferation...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544128/ https://www.ncbi.nlm.nih.gov/pubmed/23326781 http://dx.doi.org/10.4103/2277-9175.100157 |
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author | Arabpoor, Zohreh Hamidi, Gholamali Rashidi, Bahman Shabrang, Moloud Alaei, Hojjatallah Sharifi, Mohammad Reza Salami, Mahmoud Dolatabadi, Hamid Reza Dehghani Reisi, Parham |
author_facet | Arabpoor, Zohreh Hamidi, Gholamali Rashidi, Bahman Shabrang, Moloud Alaei, Hojjatallah Sharifi, Mohammad Reza Salami, Mahmoud Dolatabadi, Hamid Reza Dehghani Reisi, Parham |
author_sort | Arabpoor, Zohreh |
collection | PubMed |
description | BACKGROUND: Alzheimer's disease (AD) is a prevalent disorder with severe learning and memory defects. Because it has been demonstrated that erythropoietin (EPO) has positive effects on the central nervous system, the aim of this study was to evaluate the effect of EPO on neuronal proliferation in dentate gyrus of hippocampal formation in a well-defined model for AD. MATERIALS AND METHODS: A rat model of sporadic dementia of Alzheimer's type was established by a bilateral intracerebroventricular injection of streptozotocin (ICV-STZ). Impairment of learning and memory was confirmed 2 weeks after ICV-STZ injection by passive avoidance learning test and then rats were divided into fourgroups:Control, control-EPO, Alzheimer and Alzheimer-EPO. EPO was injected intraperitoneally every other day with a dose of 5000 IU/kg and, finally, the rats were anesthetized and decapitated for immunohistochemical study and neurogenesis investigation (by Ki67 method) in dentate gyrus of hippocampal formation. RESULTS: The results driven from the histological study showed that EPO significantly increases neuronal proliferation in dentate gyrus of hippocampus in the Alzheimer-EPO group compared with the control, control-EPO and Alzheimer groups; however, there were no differences between the other groups. CONCLUSION: Our results show that even though EPO in intact animals doesnot change neurogenesis in dentate gyrus, it can nonetheless significantly increase neurogenesis if there is an underlying disorder like neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-3544128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35441282013-01-16 Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease Arabpoor, Zohreh Hamidi, Gholamali Rashidi, Bahman Shabrang, Moloud Alaei, Hojjatallah Sharifi, Mohammad Reza Salami, Mahmoud Dolatabadi, Hamid Reza Dehghani Reisi, Parham Adv Biomed Res Original Article BACKGROUND: Alzheimer's disease (AD) is a prevalent disorder with severe learning and memory defects. Because it has been demonstrated that erythropoietin (EPO) has positive effects on the central nervous system, the aim of this study was to evaluate the effect of EPO on neuronal proliferation in dentate gyrus of hippocampal formation in a well-defined model for AD. MATERIALS AND METHODS: A rat model of sporadic dementia of Alzheimer's type was established by a bilateral intracerebroventricular injection of streptozotocin (ICV-STZ). Impairment of learning and memory was confirmed 2 weeks after ICV-STZ injection by passive avoidance learning test and then rats were divided into fourgroups:Control, control-EPO, Alzheimer and Alzheimer-EPO. EPO was injected intraperitoneally every other day with a dose of 5000 IU/kg and, finally, the rats were anesthetized and decapitated for immunohistochemical study and neurogenesis investigation (by Ki67 method) in dentate gyrus of hippocampal formation. RESULTS: The results driven from the histological study showed that EPO significantly increases neuronal proliferation in dentate gyrus of hippocampus in the Alzheimer-EPO group compared with the control, control-EPO and Alzheimer groups; however, there were no differences between the other groups. CONCLUSION: Our results show that even though EPO in intact animals doesnot change neurogenesis in dentate gyrus, it can nonetheless significantly increase neurogenesis if there is an underlying disorder like neurodegenerative diseases. Medknow Publications & Media Pvt Ltd 2012-08-28 /pmc/articles/PMC3544128/ /pubmed/23326781 http://dx.doi.org/10.4103/2277-9175.100157 Text en Copyright: © 2012 Arabpoor http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Arabpoor, Zohreh Hamidi, Gholamali Rashidi, Bahman Shabrang, Moloud Alaei, Hojjatallah Sharifi, Mohammad Reza Salami, Mahmoud Dolatabadi, Hamid Reza Dehghani Reisi, Parham Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease |
title | Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease |
title_full | Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease |
title_fullStr | Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease |
title_full_unstemmed | Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease |
title_short | Erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of Alzheimer's disease |
title_sort | erythropoietin improves neuronal proliferation in dentate gyrus of hippocampal formation in an animal model of alzheimer's disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544128/ https://www.ncbi.nlm.nih.gov/pubmed/23326781 http://dx.doi.org/10.4103/2277-9175.100157 |
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