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Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats

Highly active antiretroviral therapy (HAART) is considered toxic and has other life-threatening side effects. Our aim was to evaluate the haematotoxic effects of lamivudine, zidovudine, and nevirapine fixed-dose combinations in Albino Wistar rats. Fifty (50) three (3) months old male Albino Wistar r...

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Autores principales: Nubila, Thomas, Ukaejiofo, Ernest O., Nubila, Nkoyo I., Okorie, Godfrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544270/
https://www.ncbi.nlm.nih.gov/pubmed/23326679
http://dx.doi.org/10.5402/2012/309084
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author Nubila, Thomas
Ukaejiofo, Ernest O.
Nubila, Nkoyo I.
Okorie, Godfrey I.
author_facet Nubila, Thomas
Ukaejiofo, Ernest O.
Nubila, Nkoyo I.
Okorie, Godfrey I.
author_sort Nubila, Thomas
collection PubMed
description Highly active antiretroviral therapy (HAART) is considered toxic and has other life-threatening side effects. Our aim was to evaluate the haematotoxic effects of lamivudine, zidovudine, and nevirapine fixed-dose combinations in Albino Wistar rats. Fifty (50) three (3) months old male Albino Wistar rats weighing between 200 and 250 g were randomly assigned to five (5) groups (A, B, C, D, and E). Group A served as control. Two (2 mLs) of venous blood was aseptically collected on Days 5, 10, 15, 20, and 25 of treatment. Red blood cell (RBC) mean value recorded statistically significant increase (P < 0.05) in groups B and C when compared with the control group on Day 5. However, there was a statistically significant decrease (P < 0.05) in RBC, haemoglobin concentration (Hb), packed cell volume (PCV), and some red cell indices on Day 10. In addition there was no statistically significant difference (P > 0.05) in all the parameters evaluated when the test group was compared with the control on Day 25. Furthermore, there was a time-related statistically significant increase (P < 0.05) in the two major blood cells—RBC and platelet counts. From the result of this present study, it can be concluded that HAART when administered in fixed-dose combinations have no subacute haematotoxic effects.
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spelling pubmed-35442702013-01-16 Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats Nubila, Thomas Ukaejiofo, Ernest O. Nubila, Nkoyo I. Okorie, Godfrey I. ISRN Pharmacol Research Article Highly active antiretroviral therapy (HAART) is considered toxic and has other life-threatening side effects. Our aim was to evaluate the haematotoxic effects of lamivudine, zidovudine, and nevirapine fixed-dose combinations in Albino Wistar rats. Fifty (50) three (3) months old male Albino Wistar rats weighing between 200 and 250 g were randomly assigned to five (5) groups (A, B, C, D, and E). Group A served as control. Two (2 mLs) of venous blood was aseptically collected on Days 5, 10, 15, 20, and 25 of treatment. Red blood cell (RBC) mean value recorded statistically significant increase (P < 0.05) in groups B and C when compared with the control group on Day 5. However, there was a statistically significant decrease (P < 0.05) in RBC, haemoglobin concentration (Hb), packed cell volume (PCV), and some red cell indices on Day 10. In addition there was no statistically significant difference (P > 0.05) in all the parameters evaluated when the test group was compared with the control on Day 25. Furthermore, there was a time-related statistically significant increase (P < 0.05) in the two major blood cells—RBC and platelet counts. From the result of this present study, it can be concluded that HAART when administered in fixed-dose combinations have no subacute haematotoxic effects. International Scholarly Research Network 2012-12-30 /pmc/articles/PMC3544270/ /pubmed/23326679 http://dx.doi.org/10.5402/2012/309084 Text en Copyright © 2012 Thomas Nubila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nubila, Thomas
Ukaejiofo, Ernest O.
Nubila, Nkoyo I.
Okorie, Godfrey I.
Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats
title Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats
title_full Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats
title_fullStr Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats
title_full_unstemmed Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats
title_short Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats
title_sort examination of haematotoxicity of fixed-dose highly active antiretroviral drug in albino wistar rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544270/
https://www.ncbi.nlm.nih.gov/pubmed/23326679
http://dx.doi.org/10.5402/2012/309084
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