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EGFR targeting monoclonal antibody combines with an mTOR inhibitor and potentiates tumor inhibition by acting on complementary signaling hubs

Nimotuzumab, an anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibody, has been used extensively in many solid tumors and confers significant survival advantage. The antibody has limited skin toxicity and is generally well tolerated. Similar to other anti-EGFR therapies, patients may...

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Detalles Bibliográficos
Autores principales:	James, Roshan, Vishwakarma, Siddharth, Chivukula, Indira V, Basavaraj, Chetana, Melarkode, Ramakrishnan, Montero, Enrique, Nair, Pradip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544456/ https://www.ncbi.nlm.nih.gov/pubmed/23342262 http://dx.doi.org/10.1002/cam4.21

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