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Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants

BACKGROUND: The SH2B1 gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity. Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance for human body weight regulation. METHODS: We performed a mutation screen for...

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Detalles Bibliográficos
Autores principales:	Volckmar, Anna-Lena, Bolze, Florian, Jarick, Ivonne, Knoll, Nadja, Scherag, André, Reinehr, Thomas, Illig, Thomas, Grallert, Harald, Wichmann, Heinz-Erich, Wiegand, Susanna, Biebermann, Heike, Krude, Heiko, Fischer-Posovszky, Pamela, Rief, Winfried, Wabitsch, Martin, Klingenspor, Martin, Hebebrand, Johannes, Hinney, Anke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544595/ https://www.ncbi.nlm.nih.gov/pubmed/23270367 http://dx.doi.org/10.1186/1755-8794-5-65

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