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Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

BACKGROUND: Macroautophagy is an evolutionarily conserved mechanism for bulk intracellular degradation of proteins and organelles. Pathological studies have implicated macroautophagy defects in human neurodegenerative disorders of aging including Alzheimer’s disease and tauopathies. Neuronal deficie...

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Detalles Bibliográficos
Autores principales:	Inoue, Keiichi, Rispoli, Joanne, Kaphzan, Hanoch, Klann, Eric, Chen, Emily I, Kim, Jongpil, Komatsu, Masaaki, Abeliovich, Asa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544596/ https://www.ncbi.nlm.nih.gov/pubmed/22998728 http://dx.doi.org/10.1186/1750-1326-7-48

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