Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

BACKGROUND: Notch1 is a potent regulator known to play an oncogenic role in many malignancies including T-cell acute lymphoblastic leukemia (T-ALL). Tumor hypoxia and increased hypoxia-inducible factor-1α (HIF-1α) activity can act as major stimuli for tumor aggressiveness and progression. Although h...

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Detalles Bibliográficos
Autores principales: Zou, Jie, Li, Peng, Lu, Fei, Liu, Na, Dai, Jianjian, Ye, Jingjing, Qu, Xun, Sun, Xiulian, Ma, Daoxin, Park, Jino, Ji, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544631/
https://www.ncbi.nlm.nih.gov/pubmed/23289374
http://dx.doi.org/10.1186/1756-8722-6-3

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