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Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children
BACKGROUND: Acute Otitis Media (AOM) is an important and common disease of childhood. Bacteria isolated from cases of clinically problematic AOM in German children were identified and characterized. METHODS: In a prospective non-interventional study in German children between 3 months and less than...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544702/ https://www.ncbi.nlm.nih.gov/pubmed/23167692 http://dx.doi.org/10.1186/1471-2334-12-312 |
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author | Grevers, Gerhard Wiedemann, Susanne Bohn, Jan-Christof Blasius, Rolf-Werner Harder, Thomas Kroeniger, Werner Vetter, Volker Pirçon, Jean-Yves Marano, Cinzia |
author_facet | Grevers, Gerhard Wiedemann, Susanne Bohn, Jan-Christof Blasius, Rolf-Werner Harder, Thomas Kroeniger, Werner Vetter, Volker Pirçon, Jean-Yves Marano, Cinzia |
author_sort | Grevers, Gerhard |
collection | PubMed |
description | BACKGROUND: Acute Otitis Media (AOM) is an important and common disease of childhood. Bacteria isolated from cases of clinically problematic AOM in German children were identified and characterized. METHODS: In a prospective non-interventional study in German children between 3 months and less than 60 months of age with Ear, Nose and Throat Specialist –confirmed AOM, middle ear fluid was obtained by tympanocentesis (when clinically indicated) or by careful sampling of otorrhea through/at an existing perforation. RESULTS: In 100 children with severe AOM, Haemophilus influenzae was identified in 21% (18/21, 85.7% were non-typeable [NTHi]), Streptococcus pneumoniae in 10%, S. pyogenes in 13% and Moraxella catarrhalis in 1%. H. influenzae was the most frequently identified pathogen in children from 12 months of age. H. influenzae and S. pneumoniae were equally prevalent in children aged 3–11 months, but S. pyogenes was most frequently isolated in this age group. NTHi AOM disease appeared prevalent in all ages. CONCLUSIONS: NTHi, S. pneumoniae and S. pyogenes are implicated as important causes of complicated AOM in children in Germany. NTHi disease appears prevalent in all ages. The impact of vaccination to prevent NTHi and S. pneumoniae AOM may be substantial in this population and is worth investigating. |
format | Online Article Text |
id | pubmed-3544702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35447022013-01-16 Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children Grevers, Gerhard Wiedemann, Susanne Bohn, Jan-Christof Blasius, Rolf-Werner Harder, Thomas Kroeniger, Werner Vetter, Volker Pirçon, Jean-Yves Marano, Cinzia BMC Infect Dis Research Article BACKGROUND: Acute Otitis Media (AOM) is an important and common disease of childhood. Bacteria isolated from cases of clinically problematic AOM in German children were identified and characterized. METHODS: In a prospective non-interventional study in German children between 3 months and less than 60 months of age with Ear, Nose and Throat Specialist –confirmed AOM, middle ear fluid was obtained by tympanocentesis (when clinically indicated) or by careful sampling of otorrhea through/at an existing perforation. RESULTS: In 100 children with severe AOM, Haemophilus influenzae was identified in 21% (18/21, 85.7% were non-typeable [NTHi]), Streptococcus pneumoniae in 10%, S. pyogenes in 13% and Moraxella catarrhalis in 1%. H. influenzae was the most frequently identified pathogen in children from 12 months of age. H. influenzae and S. pneumoniae were equally prevalent in children aged 3–11 months, but S. pyogenes was most frequently isolated in this age group. NTHi AOM disease appeared prevalent in all ages. CONCLUSIONS: NTHi, S. pneumoniae and S. pyogenes are implicated as important causes of complicated AOM in children in Germany. NTHi disease appears prevalent in all ages. The impact of vaccination to prevent NTHi and S. pneumoniae AOM may be substantial in this population and is worth investigating. BioMed Central 2012-11-20 /pmc/articles/PMC3544702/ /pubmed/23167692 http://dx.doi.org/10.1186/1471-2334-12-312 Text en Copyright ©2012 Grevers et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Grevers, Gerhard Wiedemann, Susanne Bohn, Jan-Christof Blasius, Rolf-Werner Harder, Thomas Kroeniger, Werner Vetter, Volker Pirçon, Jean-Yves Marano, Cinzia Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children |
title | Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children |
title_full | Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children |
title_fullStr | Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children |
title_full_unstemmed | Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children |
title_short | Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children |
title_sort | identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in german children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544702/ https://www.ncbi.nlm.nih.gov/pubmed/23167692 http://dx.doi.org/10.1186/1471-2334-12-312 |
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