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Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs
The incidence of penile cancer varies between populations but is rare in developed nations. Penile cancer is associated with a number of established risk factors and associated diseases including phimosis with chronic inflammation, human papillomavirus (HPV) infection, poor hygiene and smoking. The...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544802/ https://www.ncbi.nlm.nih.gov/pubmed/23341933 http://dx.doi.org/10.1371/journal.pone.0053260 |
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author | Calmon, Marilia Freitas Mota, Mânlio Tasso de Oliveira Babeto, Érica Candido, Natália Maria Girol, Ana Paula Mendiburu, Carlos Fabian Bonilha, Jane Lopes Silvestre, Rodrigo Vellasco Duarte Rosa, Bruno Miziara Thomé, Jorge Alberto Medeiros, Gustavo Hernandez Américo Soares, Fernando Augusto Guimarães, Gustavo Cardoso de Arruda, José Germano Ferraz Oliani, Sonia Maria Villa, Luisa Lina Vassallo, José Rahal, Paula |
author_facet | Calmon, Marilia Freitas Mota, Mânlio Tasso de Oliveira Babeto, Érica Candido, Natália Maria Girol, Ana Paula Mendiburu, Carlos Fabian Bonilha, Jane Lopes Silvestre, Rodrigo Vellasco Duarte Rosa, Bruno Miziara Thomé, Jorge Alberto Medeiros, Gustavo Hernandez Américo Soares, Fernando Augusto Guimarães, Gustavo Cardoso de Arruda, José Germano Ferraz Oliani, Sonia Maria Villa, Luisa Lina Vassallo, José Rahal, Paula |
author_sort | Calmon, Marilia Freitas |
collection | PubMed |
description | The incidence of penile cancer varies between populations but is rare in developed nations. Penile cancer is associated with a number of established risk factors and associated diseases including phimosis with chronic inflammation, human papillomavirus (HPV) infection, poor hygiene and smoking. The objective of this study was to identify genes related to this type of cancer. The detection of HPV was analyzed in 47 penile squamous cell carcinoma samples. HPV DNA was detected in 48.9% of penile squamous cell carcinoma cases. High-risk HPV were present in 42.5% of cases and low-risk HPV were detected in 10.6% of penile squamous cell carcinomas. The RaSH approach identified differential expression of Annexin A1 (ANXA1), p16, RPL6, PBEF1 and KIAA1033 in high-risk HPV positive penile carcinoma; ANXA1 and p16 were overexpressed in penile squamous cells positive for high-risk HPVs compared to normal penile samples by qPCR. ANXA1 and p16 proteins were significantly more expressed in the cells from high-risk HPV-positive penile carcinoma as compared to HPV-negative tumors (p<0.0001) independently of the subtype of the carcinoma. Overexpression of ANXA1 might be mediated by HPV E6 in penile squamous cell carcinoma of patients with high-risk HPVs, suggesting that this gene plays an important role in penile cancer. |
format | Online Article Text |
id | pubmed-3544802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35448022013-01-22 Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs Calmon, Marilia Freitas Mota, Mânlio Tasso de Oliveira Babeto, Érica Candido, Natália Maria Girol, Ana Paula Mendiburu, Carlos Fabian Bonilha, Jane Lopes Silvestre, Rodrigo Vellasco Duarte Rosa, Bruno Miziara Thomé, Jorge Alberto Medeiros, Gustavo Hernandez Américo Soares, Fernando Augusto Guimarães, Gustavo Cardoso de Arruda, José Germano Ferraz Oliani, Sonia Maria Villa, Luisa Lina Vassallo, José Rahal, Paula PLoS One Research Article The incidence of penile cancer varies between populations but is rare in developed nations. Penile cancer is associated with a number of established risk factors and associated diseases including phimosis with chronic inflammation, human papillomavirus (HPV) infection, poor hygiene and smoking. The objective of this study was to identify genes related to this type of cancer. The detection of HPV was analyzed in 47 penile squamous cell carcinoma samples. HPV DNA was detected in 48.9% of penile squamous cell carcinoma cases. High-risk HPV were present in 42.5% of cases and low-risk HPV were detected in 10.6% of penile squamous cell carcinomas. The RaSH approach identified differential expression of Annexin A1 (ANXA1), p16, RPL6, PBEF1 and KIAA1033 in high-risk HPV positive penile carcinoma; ANXA1 and p16 were overexpressed in penile squamous cells positive for high-risk HPVs compared to normal penile samples by qPCR. ANXA1 and p16 proteins were significantly more expressed in the cells from high-risk HPV-positive penile carcinoma as compared to HPV-negative tumors (p<0.0001) independently of the subtype of the carcinoma. Overexpression of ANXA1 might be mediated by HPV E6 in penile squamous cell carcinoma of patients with high-risk HPVs, suggesting that this gene plays an important role in penile cancer. Public Library of Science 2013-01-14 /pmc/articles/PMC3544802/ /pubmed/23341933 http://dx.doi.org/10.1371/journal.pone.0053260 Text en © 2013 Calmon et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Calmon, Marilia Freitas Mota, Mânlio Tasso de Oliveira Babeto, Érica Candido, Natália Maria Girol, Ana Paula Mendiburu, Carlos Fabian Bonilha, Jane Lopes Silvestre, Rodrigo Vellasco Duarte Rosa, Bruno Miziara Thomé, Jorge Alberto Medeiros, Gustavo Hernandez Américo Soares, Fernando Augusto Guimarães, Gustavo Cardoso de Arruda, José Germano Ferraz Oliani, Sonia Maria Villa, Luisa Lina Vassallo, José Rahal, Paula Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs |
title | Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs |
title_full | Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs |
title_fullStr | Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs |
title_full_unstemmed | Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs |
title_short | Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs |
title_sort | overexpression of anxa1 in penile carcinomas positive for high-risk hpvs |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544802/ https://www.ncbi.nlm.nih.gov/pubmed/23341933 http://dx.doi.org/10.1371/journal.pone.0053260 |
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