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Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs

Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12...

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Detalles Bibliográficos
Autores principales:	Afrikanova, Tatiana, Serruys, Ann-Sophie K., Buenafe, Olivia E. M., Clinckers, Ralph, Smolders, Ilse, de Witte, Peter A. M., Crawford, Alexander D., Esguerra, Camila V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544809/ https://www.ncbi.nlm.nih.gov/pubmed/23342097 http://dx.doi.org/10.1371/journal.pone.0054166

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