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Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development
Lymphangiogenesis is a highly regulated process that involves the reprogramming of venous endothelial cells into early lymphatic endothelial cells. This reprogramming not only displays a polarized expression pattern from the cardinal vein, but also demonstrates vascular specificity; early lymphatics...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544876/ https://www.ncbi.nlm.nih.gov/pubmed/23341894 http://dx.doi.org/10.1371/journal.pone.0052197 |
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author | Kim, Harold Cruz, Maribelle Bourdeau, Annie Dumont, Daniel J. |
author_facet | Kim, Harold Cruz, Maribelle Bourdeau, Annie Dumont, Daniel J. |
author_sort | Kim, Harold |
collection | PubMed |
description | Lymphangiogenesis is a highly regulated process that involves the reprogramming of venous endothelial cells into early lymphatic endothelial cells. This reprogramming not only displays a polarized expression pattern from the cardinal vein, but also demonstrates vascular specificity; early lymphatics only develop from the cardinal vein and not the related dorsal aorta. In our transgenic model of lymphangiogenesis, we demonstrate that Prox1 overexpression has the ability to reprogram venous endothelium but not early arterial endothelial cells in vivo, in spite of the fact that Prox1 expression is forced onto both vascular beds. Our observations suggest that this specificity during embryogenesis may be due to cell-cell interactions between the developing arterial endothelial cells and smooth muscle cells. These conclusions have far reaching implications on how we understand the vascular specificity of lymphangiogenesis. |
format | Online Article Text |
id | pubmed-3544876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35448762013-01-22 Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development Kim, Harold Cruz, Maribelle Bourdeau, Annie Dumont, Daniel J. PLoS One Research Article Lymphangiogenesis is a highly regulated process that involves the reprogramming of venous endothelial cells into early lymphatic endothelial cells. This reprogramming not only displays a polarized expression pattern from the cardinal vein, but also demonstrates vascular specificity; early lymphatics only develop from the cardinal vein and not the related dorsal aorta. In our transgenic model of lymphangiogenesis, we demonstrate that Prox1 overexpression has the ability to reprogram venous endothelium but not early arterial endothelial cells in vivo, in spite of the fact that Prox1 expression is forced onto both vascular beds. Our observations suggest that this specificity during embryogenesis may be due to cell-cell interactions between the developing arterial endothelial cells and smooth muscle cells. These conclusions have far reaching implications on how we understand the vascular specificity of lymphangiogenesis. Public Library of Science 2013-01-14 /pmc/articles/PMC3544876/ /pubmed/23341894 http://dx.doi.org/10.1371/journal.pone.0052197 Text en © 2013 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kim, Harold Cruz, Maribelle Bourdeau, Annie Dumont, Daniel J. Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development |
title | Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development |
title_full | Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development |
title_fullStr | Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development |
title_full_unstemmed | Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development |
title_short | Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development |
title_sort | cell-cell interactions influence vascular reprogramming by prox1 during embryonic development |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544876/ https://www.ncbi.nlm.nih.gov/pubmed/23341894 http://dx.doi.org/10.1371/journal.pone.0052197 |
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