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Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development

Lymphangiogenesis is a highly regulated process that involves the reprogramming of venous endothelial cells into early lymphatic endothelial cells. This reprogramming not only displays a polarized expression pattern from the cardinal vein, but also demonstrates vascular specificity; early lymphatics...

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Detalles Bibliográficos
Autores principales: Kim, Harold, Cruz, Maribelle, Bourdeau, Annie, Dumont, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544876/
https://www.ncbi.nlm.nih.gov/pubmed/23341894
http://dx.doi.org/10.1371/journal.pone.0052197
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author Kim, Harold
Cruz, Maribelle
Bourdeau, Annie
Dumont, Daniel J.
author_facet Kim, Harold
Cruz, Maribelle
Bourdeau, Annie
Dumont, Daniel J.
author_sort Kim, Harold
collection PubMed
description Lymphangiogenesis is a highly regulated process that involves the reprogramming of venous endothelial cells into early lymphatic endothelial cells. This reprogramming not only displays a polarized expression pattern from the cardinal vein, but also demonstrates vascular specificity; early lymphatics only develop from the cardinal vein and not the related dorsal aorta. In our transgenic model of lymphangiogenesis, we demonstrate that Prox1 overexpression has the ability to reprogram venous endothelium but not early arterial endothelial cells in vivo, in spite of the fact that Prox1 expression is forced onto both vascular beds. Our observations suggest that this specificity during embryogenesis may be due to cell-cell interactions between the developing arterial endothelial cells and smooth muscle cells. These conclusions have far reaching implications on how we understand the vascular specificity of lymphangiogenesis.
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spelling pubmed-35448762013-01-22 Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development Kim, Harold Cruz, Maribelle Bourdeau, Annie Dumont, Daniel J. PLoS One Research Article Lymphangiogenesis is a highly regulated process that involves the reprogramming of venous endothelial cells into early lymphatic endothelial cells. This reprogramming not only displays a polarized expression pattern from the cardinal vein, but also demonstrates vascular specificity; early lymphatics only develop from the cardinal vein and not the related dorsal aorta. In our transgenic model of lymphangiogenesis, we demonstrate that Prox1 overexpression has the ability to reprogram venous endothelium but not early arterial endothelial cells in vivo, in spite of the fact that Prox1 expression is forced onto both vascular beds. Our observations suggest that this specificity during embryogenesis may be due to cell-cell interactions between the developing arterial endothelial cells and smooth muscle cells. These conclusions have far reaching implications on how we understand the vascular specificity of lymphangiogenesis. Public Library of Science 2013-01-14 /pmc/articles/PMC3544876/ /pubmed/23341894 http://dx.doi.org/10.1371/journal.pone.0052197 Text en © 2013 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kim, Harold
Cruz, Maribelle
Bourdeau, Annie
Dumont, Daniel J.
Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development
title Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development
title_full Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development
title_fullStr Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development
title_full_unstemmed Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development
title_short Cell-Cell Interactions Influence Vascular Reprogramming by Prox1 during Embryonic Development
title_sort cell-cell interactions influence vascular reprogramming by prox1 during embryonic development
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544876/
https://www.ncbi.nlm.nih.gov/pubmed/23341894
http://dx.doi.org/10.1371/journal.pone.0052197
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