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Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties. OBJECTIVES: The study aimed to assess early EPCs levels and...

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Autores principales: Malli, Foteini, Koutsokera, Angela, Paraskeva, Efrosini, Zakynthinos, Epaminondas, Papagianni, Maria, Makris, Dimosthenes, Tsilioni, Irene, Molyvdas, Paschalis Adam, Gourgoulianis, Konstantinos I., Daniil, Zoe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544914/
https://www.ncbi.nlm.nih.gov/pubmed/23341966
http://dx.doi.org/10.1371/journal.pone.0053658
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author Malli, Foteini
Koutsokera, Angela
Paraskeva, Efrosini
Zakynthinos, Epaminondas
Papagianni, Maria
Makris, Dimosthenes
Tsilioni, Irene
Molyvdas, Paschalis Adam
Gourgoulianis, Konstantinos I.
Daniil, Zoe
author_facet Malli, Foteini
Koutsokera, Angela
Paraskeva, Efrosini
Zakynthinos, Epaminondas
Papagianni, Maria
Makris, Dimosthenes
Tsilioni, Irene
Molyvdas, Paschalis Adam
Gourgoulianis, Konstantinos I.
Daniil, Zoe
author_sort Malli, Foteini
collection PubMed
description BACKGROUND: Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties. OBJECTIVES: The study aimed to assess early EPCs levels and EPCs endogenous vascular endothelial growth factor (VEGF) expression in IPF. In order to examine alterations in the mobilization of EPCs from the bone marrow we measured plasma VEGF. MAIN RESULTS: Twenty-three patients with IPF and fifteen healthy subjects were included. The number of early EPCs colonies was markedly reduced in IPF patients vs controls (6.00±6.49 vs 49.68±16.73, respectively, p<0.001). EPCs were further decreased in patients presenting systolic pulmonary arterial pressure (sPAP)≥35 mmHg. The number of colonies per well correlated negatively with P((A-a))O(2) (r =  −0.750, p<0.001). Additionally, VEGF mRNA levels were significantly increased in IPF patients. There were no differences observed in VEGF plasma levels in IPF patients when compared to controls. CONCLUSIONS: The current data suggest that inadequate levels of early EPCs may potentially contribute to suppressed repair and recovery of the damaged pulmonary endothelium and thereby may drive the sequence of events in profibrogenic direction. Increased VEGFmRNA levels in the clinical context of IPF may represent a compensatory mechanism to overcome reduced EPCs levels.
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spelling pubmed-35449142013-01-22 Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept Malli, Foteini Koutsokera, Angela Paraskeva, Efrosini Zakynthinos, Epaminondas Papagianni, Maria Makris, Dimosthenes Tsilioni, Irene Molyvdas, Paschalis Adam Gourgoulianis, Konstantinos I. Daniil, Zoe PLoS One Research Article BACKGROUND: Idiopathic pulmonary fibrosis (IPF) has been associated with abnormal vascular remodeling. Bone marrow derived endothelial progenitor cells (EPCs) are considered to possess lung tissue repair and vascular remodeling properties. OBJECTIVES: The study aimed to assess early EPCs levels and EPCs endogenous vascular endothelial growth factor (VEGF) expression in IPF. In order to examine alterations in the mobilization of EPCs from the bone marrow we measured plasma VEGF. MAIN RESULTS: Twenty-three patients with IPF and fifteen healthy subjects were included. The number of early EPCs colonies was markedly reduced in IPF patients vs controls (6.00±6.49 vs 49.68±16.73, respectively, p<0.001). EPCs were further decreased in patients presenting systolic pulmonary arterial pressure (sPAP)≥35 mmHg. The number of colonies per well correlated negatively with P((A-a))O(2) (r =  −0.750, p<0.001). Additionally, VEGF mRNA levels were significantly increased in IPF patients. There were no differences observed in VEGF plasma levels in IPF patients when compared to controls. CONCLUSIONS: The current data suggest that inadequate levels of early EPCs may potentially contribute to suppressed repair and recovery of the damaged pulmonary endothelium and thereby may drive the sequence of events in profibrogenic direction. Increased VEGFmRNA levels in the clinical context of IPF may represent a compensatory mechanism to overcome reduced EPCs levels. Public Library of Science 2013-01-14 /pmc/articles/PMC3544914/ /pubmed/23341966 http://dx.doi.org/10.1371/journal.pone.0053658 Text en © 2013 Malli et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Malli, Foteini
Koutsokera, Angela
Paraskeva, Efrosini
Zakynthinos, Epaminondas
Papagianni, Maria
Makris, Dimosthenes
Tsilioni, Irene
Molyvdas, Paschalis Adam
Gourgoulianis, Konstantinos I.
Daniil, Zoe
Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept
title Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept
title_full Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept
title_fullStr Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept
title_full_unstemmed Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept
title_short Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept
title_sort endothelial progenitor cells in the pathogenesis of idiopathic pulmonary fibrosis: an evolving concept
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544914/
https://www.ncbi.nlm.nih.gov/pubmed/23341966
http://dx.doi.org/10.1371/journal.pone.0053658
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